AI Article Synopsis
- Recent studies reveal that the nonstructural protein 1 (A/NS1) of the influenza A virus binds to and activates phosphatidylinositol 3-kinase (PI3K), which helps stop premature cell death during viral spread.
- In contrast, the nonstructural protein 1 (B/NS1) from the influenza B virus does not have the ability to activate PI3K signaling.
- This indicates that activating PI3K is a unique function of A/NS1 that distinguishes it from the B/NS1 protein of influenza B virus.
Article Abstract
Recently it has been shown by several laboratories that the influenza A virus nonstructural protein 1 (A/NS1) binds and activates phosphatidylinositol 3-kinase (PI3K). This function of the protein is likely to prevent premature apoptosis induction during viral propagation. Here we show that the B/NS1 protein completely lacks the capacity to induce PI3K signaling. Thus, PI3K activation is another unique function of A/NS1 that is different from the action of its influenza B virus counterpart.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2168765 | PMC |
| http://dx.doi.org/10.1128/JVI.01216-07 | DOI Listing |
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