AI Article Synopsis
- The study explores the timing of blood sample collection for IgE antibody analysis during anaphylaxis, challenging the belief that samples must be taken weeks later.
- Researchers measured IgE levels against suxamethonium before, during, and after an anaphylactic reaction to determine if immediate sampling was viable.
- Findings show that IgE antibody levels collected up to 6 hours post-reaction are similar to those taken before and after the incident, indicating that immediate samples can effectively identify the allergen involved.
Article Abstract
Background: The general understanding is that a blood sample for analysis of immunoglobulin (Ig) E antibodies to an allergen suspected to cause an anaphylaxis cannot be drawn until several weeks after the reaction. As this is most unpractical, the changes in IgE antibody levels during anaphylaxis were studied to evaluate the possibility of using samples drawn at the time of the reaction.
Methods: Immunoglobulin E antibodies to suxamethonium were quantitated with ImmunoCAP before, during and after an anaphylactic reaction occurring during anaesthesia using neuromuscular blocking agents.
Results: Serum IgE antibody concentrations against suxamethonium in blood samples collected up to 6 h after the reaction were not different from those in samples drawn before or days and weeks after the anaphylaxis.
Conclusions: A serum sample intended to trace the drug involved in an IgE-mediated anaphylactic reaction can be drawn in direct relation to the reaction.
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| http://dx.doi.org/10.1111/j.1398-9995.2007.01498.x | DOI Listing |
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