The killing of microorganisms by neutrophils causes degranulation of azurophilic, specific, and gelatinase granules into the formed phagolysosomes. During the degranulation process, increased surface expression of CD63 (localized in the azurophilic granules of resting neutrophils) and CD66b/CD67 (from specific granules) can be detected. This results from the fusion of the granule membrane, containing these markers, with a plasma membrane. Release of granule content into the phagolysosomes or the extracellular environment occurs not only upon proper cell activation but also upon tissue injury. We compared expression of degranulation markers on neutrophils from chronic granulomatous disease (CGD) patients and healthy volunteers. Surface expression of CD63 in non-stimulated and phorbol 12-myristate 13-acetate (PMA)-stimulated neutrophils, bactericidal activity of serum, and alpha-defensins level (HNP 1-3) in plasma of CGD patients were significantly higher in comparison with healthy volunteers. At the same time, the levels of intracellular HNP 1-3 in CGD neutrophils were lower than in normal neutrophils. Thus, our data revealed augmented degranulation of azurophilic neutrophil granules in CGD, which might play a role in tissue destruction observed in this disease.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/978-0-387-72005-0_7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Involvement of Species in Spotty Liver Disease-like Lesions in Broiler Chickens Detected at Meat Inspections in Miyazaki Prefecture, Japan.
Microorganisms
November 2024
Center for Animal Disease Control, University of Miyazaki, Miyazaki 889-2192, Japan.
Spotty liver disease (SLD) affects free-range laying hens, leading to mortality and reduced egg production. species, including , have been associated with SLD cases worldwide. However, the cause of SLD-like lesions found in broilers in Japan still remains unclear.
View Article and Find Full Text PDFRheumatic Manifestations of Sarcoidosis.
Diagnostics (Basel)
December 2024
North Bristol NHS Foundation Trust, Bristol BS10 5NB, UK.
Sarcoidosis is a multisystem granulomatous inflammatory disorder, of unknown aetiology, which causes a wide spectrum of clinical phenotypes. It can present at any age, most commonly between 20 and 60 years, with a roughly equal sex distribution. Diagnosis is often delayed due to multiple diagnostic mimics, particularly joint disease.
View Article and Find Full Text PDFRepurposing Historic Drugs for Neutrophil-Mediated Inflammation in Skin Disorders.
Biomolecules
November 2024
Dermatology Unit, Department of Medicine (DIMED), University of Padua, 35121 Padova, Italy.
Neutrophil-mediated inflammation is a key feature of immune-mediated chronic skin disorders, but the mechanistic understanding of neutrophil involvement in these conditions remains incomplete. Dapsone, colchicine, and tetracyclines are established drugs within the dermatologist's therapeutic armamentarium that are credited with potent anti-neutrophilic effects. Anti-neutrophilic drugs have established themselves as versatile agents in the treatment of a wide range of dermatological conditions.
View Article and Find Full Text PDFUpdate on actinomycetoma treatment: linezolid in the treatment of actinomycetomas due to spp and resistant to conventional treatments.
Expert Rev Anti Infect Ther
January 2025
Dermatology Department, Brighton General Hospital, University Hospitals Sussex NHS Foundation Trust, Brighton, UK.
Introduction: Mycetoma is a chronic granulomatous infection, common throughout tropical regions, and is considered a neglected disease that mostly affects impoverished populations. Mycetoma is divided into eumycetoma, caused by fungi, and actinomycetoma, caused by filamentous bacteria. Clinical presentation is distinctive, and making the diagnosis is usually not difficult; however, access to safe and effective treatments is a major challenge.
View Article and Find Full Text PDFArticle Synopsis
- Sarcoidosis is a multisystem disease that commonly affects African American women and people of Scandinavian descent, characterized by noncaseating granulomas.
- A 29-year-old African American male presented with recurrent symptoms related to gallstones, specifically right upper quadrant pain after eating, and was found to have cholelithiasis on imaging.
- During an elective surgery for gallbladder removal, liver lesions were discovered, and a biopsy revealed noncaseating granulomas consistent with sarcoidosis, indicating an unusual manifestation of the disease in the liver and lymph nodes.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!