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Effectiveness and acceptability of a 24-h interval versus a 48-h interval between mifepristone intake and misoprostol administration for in-hospital abortion at 9-20 gestational weeks: an international, open-label, randomised, controlled, non-inferiority trial.
Lancet Glob Health
January 2025
Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden; WHO Collaborating Centre, Karolinska University Hospital, Stockholm, Sweden.
Background: Optimising management of second-trimester medical abortion is important, as complications increase with gestational age. We aimed to compare a 24-h interval with a 48-h interval between mifepristone intake and misoprostol administration in in-hospital, second-trimester medical abortion for effectiveness and acceptability.
Methods: This open-label, randomised, controlled, non-inferiority trial was conducted at nine hospitals in India, Sweden, Thailand, and Viet Nam among adults undergoing medical abortion for a singleton viable pregnancy at a gestation of between 9 weeks and 20 weeks.
Ultrasound diagnosis of first trimester umbilical cord entanglement in monochorionic monoamniotic twins - case report and review of the literature.
BMC Pregnancy Childbirth
November 2024
Hadassah University Hospital, Mt Scopus, Obstetrics and Gynecology, Jerusalem, Israel.
Article Synopsis
- * A 32-year-old woman undergoing assisted reproductive technology showed two embryos with regular heartbeats and tightly entangled umbilical cords at 8.5 weeks gestation, identified through various ultrasound techniques.
- * The findings suggest that UCE can be diagnosed as early as eight weeks of gestation, but may indicate a poor prognosis for the pregnancy.
Untargeted Lipidomic Profiling of Amniotic Fluid Reveals Dysregulated Lipid Metabolism in Healthy Normal-Weight Mothers with Fetal Macrosomia.
Nutrients
November 2024
School of Human Nutrition, McGill University, Ste-Anne de Bellevue, QC H9X 3V9, Canada.
Article Synopsis
- - The study aims to investigate the lipid profiles in early 2nd trimester amniotic fluid of healthy normal-weight mothers who have either large-for-gestational age (LGA) or appropriate-for-gestational age (AGA) infants, while also examining the relationship between lipid profiles and insulin/glucose levels.
- - Researchers analyzed bio-banked amniotic fluid samples using advanced mass spectrometry techniques, comparing 15 LGA infants to 15 AGA infants and identified significant differences, including higher levels of specific phosphatidic acid species in LGA samples.
- - The results suggest that even in healthy normal-weight mothers, there are early signs of disrupted lipid metabolism when carrying LGA infants, with no correlation found
Metabolomic biomarkers in amniotic fluid for early diagnosis of preterm birth and fetal growth restriction.
Folia Med (Plovdiv)
October 2024
Aristotle University of Thessaloniki, Thessaloniki, Greece.
Preterm birth, affecting about 10% of pregnancies, significantly contributes to perinatal morbidity and mortality. Recent research indicates that metabolomics could enhance pregnancy outcomes and reduce costs by identifying biomarkers related to common pregnancy complications. Our team focused on analyzing amniotic fluid collected during the second trimester to identify potential biomarkers for preterm birth using 1H-NMR metabolomic analysis.
View Article and Find Full Text PDFPrenatal diagnosis of 9q34.3 microdeletion-associated Kleefstra syndrome in a pregnancy complicated by polyhydramnios: A case report and literature review.
Taiwan J Obstet Gynecol
November 2024
Department of Obstetrics and Gynecology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address:
Objective: Kleefstra Syndrome (KS) is a rare genetic disorder caused by a deletion at 9q34.3. Studies showed that various heart defects are observed in 41-43% of patients and abnormal features on brain imaging in 58-63%.
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