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Rhenium-186 hydroxyethylidenediphosphonate (186Re HEDP) for the treatment of hemophilic arthropathy: first results. | LitMetric

AI Article Synopsis

  • - The study aimed to test the effectiveness of rhenium-186 hydroxyethylidenediphosphonate (Re HEDP) for relieving pain in patients suffering from hemophilic arthropathies, focusing on those with pain in at least three joints.
  • - Twelve patients received a single intravenous dose of Re HEDP, and their pain levels were measured before treatment and again 12 weeks later using a visual analog scale (VAS).
  • - Results indicated that 69.4% of the most affected joints showed improvement in pain symptoms, with an overall reduction in general pain status, but many joints remained painful post-treatment or developed new pain issues.

Article Abstract

Objectives: The aim of this study was to evaluate the efficacy of a systemic application of rhenium-186 hydroxyethylidenediphosphonate (Re HEDP) for pain treatment in patients with hemophilic arthropathies.

Methods: Twelve patients with hemophilic arthropathy with at least 3 involved joints with persistent pain were included in this prospective study. A single dose of 15 mCi (555 MBq) Re HEDP was administered intravenously. Before and 12 weeks after treatment, pain assessment was performed using the visual analog scale (VAS). The pain status assessment included the general status, pain of all joints affected, and pain of the 3 mostly involved joints. Furthermore, quality of life was assessed.

Results: With regard to the 3 most involved joints, an improvement of the pain symptoms in 25 of 36 (69.4%) joints was observed. With regard to all involved joints a median of 3 joints per patient improved after Re HEDP therapy. General pain status after treatment was 2.0 VAS points lower as compared with pretreatment. The total number of involved joints remained unchanged in 7 patients, increased in 1 patient, and decreased in the remaining 4 patients.

Conclusions: The results of this study show an improvement of the pain symptoms of the involved joints 12 weeks after therapy with Re HEDP in patients with hemophilic arthropathy. The only moderate success regarding a reduction of the total number of involved joints is by the fact that despite this improvement most affected joints remained still painful on a lower level after the therapy or due to newly affected joints not painful before initiation of the radionuclide therapy.

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Source
http://dx.doi.org/10.1097/AJP.0b013e318123fd4eDOI Listing

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