Reports of sex steroid receptor expression in chordoma suggest that these tumors may be responsive to hormone manipulation therapy. Immunohistochemical stains for estrogen receptor (ER)-alpha, ER-beta, progesterone receptor (PR), androgen receptor (AR), and cyclooxygenase 2 (COX-2), were performed on a tissue microarray containing 21 samples of chordoma. Most chordomas expressed COX-2, ER-beta, and AR, whereas ER-alpha and PR stains were negative in all cases. ER-beta expression did not correlate with AR expression (P = .4142; McNemar test). There were no statistically significant correlations between the expression of any of these markers and anatomic location of tumor, patient sex, patient age, or disease-free survival. Chordomas commonly express COX-2, AR, and ER-beta. These findings may have therapeutic implications concerning the use of agents that inhibit or modulate these signaling molecules.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1309/8T2NPHLK5X5WQ3E7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Intraoperative Molecular Imaging With Pafolacianine: Histologic Characteristics of Identified Nodules.
Clin Lung Cancer
November 2024
Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH. Electronic address:
Background: With increased early detection efforts, surgery for early-stage lung cancer is expected to rise. Pafolacianine is the first FDA approved targeted optical imaging agent indicated as an adjunct for intraoperative identification of malignant and nonmalignant pulmonary lesions in adult patients with known or suspected cancer in the lung.
Methods: This is a retrospective review of the malignant and nonmalignant lesions identified by pafolacianine with intraoperative molecular imaging (IMI) in the multi-center Phase 2 and Phase 3 ELUCIDATE clinical trials.
Developmental gene expression in skull-base chordomas and chondrosarcomas.
J Neurooncol
December 2024
Department of Neurosurgery, Maastricht University Medical Center, P. Debyelaan 25, 6202 AZ, Maastricht, The Netherlands.
Purpose: Chordomas are malignant tumors of the axial spine and skull base, and they are notorious for their poor treatment response. Differentiating these tumors from comparatively less malignant chondrosarcomas is crucial for treatment and prognostication. Both tumor types differ in their developmental origin.
View Article and Find Full Text PDFMulti-omics analysis unveils the role of inflammatory cancer-associated fibroblasts in chordoma progression.
J Pathol
January 2025
Department of Musculoskeletal Tumor, Peking University People's Hospital, Peking University, Beijing, PR China.
Cancer-associated fibroblasts (CAFs) constitute the primary cellular component of the stroma in chordomas, characterized by an abundance of mucinous stromal elements, potentially facilitating their initiation and progression; however, this inference has yet to be fully confirmed. In this study, single-cell RNA sequencing (scRNA-seq), spatial transcriptomics (ST), bulk RNA-seq, multiplexed quantitative immunofluorescence (QIF), and in vivo and in vitro experiments were performed to determine the heterogeneity, spatial distribution, and clinical significance of CAFs in chordoma. ScRNA-seq was performed on 87,693 single cells derived from seven tumor samples and four control nucleus pulposus samples.
View Article and Find Full Text PDFExtraaxial Poorly Differentiated Chordoma: Clinicopathologic and Molecular Genetic Characterization.
Mod Pathol
November 2024
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota. Electronic address:
Article Synopsis
- In a study of six EAPDC cases, histological features were similar to axial PDC, showing malignant cell characteristics, and genetic analysis revealed common loss of the SMARCB1 gene.
- Follow-up revealed significant clinical challenges, including local recurrences and metastasis within months of surgery, highlighting the aggressive nature and poor prognosis of these rare tumors.
Brachyury Expression in Atypical Teratoid/Rhabdoid Tumor.
Int J Surg Pathol
November 2024
Department of Pathology, Hacettepe University Faculty of Medicine, Ankara, Turkiye.
Article Synopsis
- Atypical teratoid/rhabdoid tumor (AT/RT) is a rare and aggressive brain tumor in children linked to specific genetic alterations, particularly in the SWI/SNF complex.
- The study analyzed 44 AT/RT samples from 40 patients and found that most tumors were negative for brachyury expression, with only two positive cases seen in very young children with clivus involvement.
- The findings suggest that brachyury expression might help differentiate poorly differentiated chordoma from AT/RT, especially when considering tumor morphology and DNA methylation patterns.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!