AI Article Synopsis
- The study aimed to investigate the link between arsenic metabolism and DNA oxidative damage among workers in an arsenic mill in Yunnan province.
- Researchers measured urinary levels of organic arsenic and DNA damage markers (8-hydroxydeoxyguanine) in 37 highly exposed workers, 16 with mild exposure, and 28 controls with no exposure.
- Results indicated higher levels of both arsenic and DNA damage in exposed workers, particularly in females, suggesting that arsenic exposure causes significant oxidative damage to DNA.
Article Abstract
Objective: To evaluate the association between metabolism of arsenic and DNA oxidative damage in workers in a arsenic mill.
Methods: Urinary organic arsenic and 8-hydroxydeoxyguanine were detected in 37 workers highly exposed to arsenic and 16 administrative and logistic staff with mild exposure in a arsenic mill in Yunnan province, and also 28 local people who did not have the exposure in the near past time. The correlation between metabolism of arsenic and DNA oxidative damage was evaluated.
Results: The urinary organic arsenic concentration was respectively (0.48 +/- 0.37) mg/L and (0.08 +/- 0.05) mg/L for men with high and low exposure, and was respectively 0.11 mg/L and (0.30 +/- 0.24) mg/ L for women with high and low exposure, while it was lower than 0.02 mg/L in the controls. Urinary 8-hydroxydeoxyguanine concentration was (18.07 +/- 11.68) micromol/mol creatinine, (11.79 +/- 8.25) micromol/mol creatinine, (10.07 +/- 3.04) micromol/mol creatinine for the males with high and low exposure and of controls, respectively, (P < 0.05), and it was 84.35 micromol/mol creatinine, (21.27 +/- 5.89) micromol/mol creatinine, (14.43 +/- 2.58) micromol/mol creatinine for females with high and low exposure and of controls, respectively. The female workers exposed to arsenic had higher urinary 8-hydroxydeoxyguanine levels than males did (P < 0.05). The increased tendencies of urinary 8-hydroxydeoxyguanine levels with the organic arsenic concentration were found in workers (r(s) = 0.279, P = 0.019).
Conclusion: Occupational individuals exposed to arsenic have obvious DNA oxidative damage, which is more severe in females. The difference of metabolism of arsenic may play a key role.
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