We report herein two patients with acquired fatty replacement of the distal pancreas, who underwent pancreaticoduodenectomy (PD) without reconstruction of remnant pancreas. Slow-growing tumors resulted in obstructive pancreatitis of the distal pancreas and insufficient focal blood flow, resulting in marked atrophy of the pancreas and fatty replacement. Suspected disappearance and fatty replacement of the body and tail of the pancreas were noted. In this situation, the PD procedure can be achieved without the reconstruction of remnant pancreas. Interestingly, the patients did not require insulin support postoperatively.

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