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Comparative perioperative narcotic use in tlif patients: Spinal versus general anesthesia in a retrospective cohort study of 180 cases in hospital and ambulatory settings.
Clin Neurol Neurosurg
March 2025
Vail-Summit Orthopaedics and Neurosurgery, 180 S Frontage Rd W, Suite 2700, Vail, CO 81657, United States.
Objectives: To implement an integrated anesthesia and surgery protocol of improved postoperative pain control to facilitate transitioning of minimally invasive transforaminal lumbar interbody fusion (MI-TLIF) from a hospital to an ambulatory surgery center setting by lowering postoperative (in-facility) narcotic consumption and length of stay (LOS) transitioning from general to awake spinal anesthesia.
Methods: A retrospective cohort study of 180 patients who received awake or general anesthesia (GA) MI-TLIF from 2017 to 2023.
Results: Among 180 MI-TLIF patients, 101 (56 %) received awake protocol and 79 (44 %) received general anesthesia.
Synchronisation of multiple unconnected inertial measurement units using software correction.
J Biomech
March 2025
School of Biomedical, Nutritional, and Sport Sciences, Newcastle University, Newcastle, UK. Electronic address:
A major challenge in capturing multi-segmental movements with unconnected inertial measurement units (IMUs) is synchronisation between IMUs. The aims of this study were to assess the reproducibility of desynchronisation rates between unconnected IMUs (Axivity, Ax6) commonly used in human movement studies and to determine the accuracy of predicted (corrected) clock differences under different conditions. In the first two experiments, we report that rates of desynchronisation between IMU pairs were linear, unique to each pair, and reproducible within and between sessions.
View Article and Find Full Text PDFHamiltonian replica-exchange method α-REMD for ring spearing elimination in polymers.
J Chem Phys
March 2025
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., Moscow 119991, Russian Federation.
Accurate prediction of polymer properties using molecular dynamics (MD) simulations requires a properly relaxed starting structure. Polymer models built from scratch by specialized algorithms (self-avoiding random walk, Monte Carlo, etc.) are far from relaxed and, moreover, often possess a large number of structural defects: close contacts between atoms, wrong bond distances, voids, unfavorable molecular conformations or packing, etc.
View Article and Find Full Text PDFMacrophage peroxisomes guide alveolar regeneration and limit SARS-CoV-2 tissue sequelae.
Science
March 2025
Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, VA, USA.
Peroxisomes are vital but often overlooked metabolic organelles. We found that excessive interferon signaling remodeled macrophage peroxisomes. This loss of peroxisomes impaired inflammation resolution and lung repair during severe respiratory viral infections.
View Article and Find Full Text PDFPhysical Activity Monitoring in Children in the 1-Year After 3 or More Days of Invasive Ventilation: Feasibility of Using Accelerometers.
Pediatr Crit Care Med
March 2025
Department of Pediatrics, Section of Critical Care, University of Arkansas for Medical Sciences and Arkansas Children's, Little Rock, AR.
Objectives: To measure physical activity in a cohort of children who survived greater than or equal to 3 days of invasive ventilation.
Design: Prospective cohort study (2018-2021).
Setting: Quaternary children's hospital PICU.
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