AI Article Synopsis
- Glioma is a fast-growing and invasive brain cancer that often resists current treatment options.
- Recent research has focused on the role of ion channels in glioma cells, suggesting they could be targets for new biochemical therapies.
- The paper reviews the effectiveness of temozolomide and highlights new studies on various ion channels and their modulators, proposing potential future avenues for glioma treatment.
Article Abstract
Glioma is a highly invasive, rapidly spreading form of brain cancer that is resistant to surgical and medical treatment. The recent progresses made in intracellular and ion channels of glioma cells provide a potential new approach for biochemical therapy of brain tumor. In this paper, we reviewed clinical data on chemotherapy by temozolomide and results from new studies on voltage-gated potassium channels, large-conductance Ca(2+)-activated K(+) channels, volume-activated chloride channels, glioma-specific chloride channel and their modulators. These new findings may represent future directions for brain tumor studies and treatment.
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| http://dx.doi.org/10.1016/j.bbrc.2007.07.167 | DOI Listing |
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