AI Article Synopsis
- A case study of an 8-year-old boy with a red cell membrane disorder who developed portal vein thrombosis following laparoscopic surgery, specifically cholecystectomy and splenectomy.
- The child had a history of right hemiparesis due to a hypoxic-ischemic event at birth and carried a specific genetic mutation related to folate metabolism.
- Treatment involved the use of intravenous heparin and aspirin, leading to symptom relief within three days and complete resolution of the thrombosis two months later, alongside a discussion of potential causes for the thrombosis based on existing literature.
Article Abstract
We report the case of an 8-year-old boy with a red cell membrane disorder who developed, soon after undergoing laparoscopic cholecystectomy and splenectomy, complete thrombosis of the right branch and a partial occlusion of the left branch of the portal vein. The child was affected by a right hemiparesis because of a hypoxic-ischemic disorder that occurred in the first hours of life and was heterozygous for the methylenetetrahydrofolate reductase gene mutation 677C-T. Intravenous heparin and aspirin were initiated on postoperative day 7. Heparin treatment was switched to the subcutaneous route after the first 24 hours. The symptoms subsided 3 days after the beginning of treatment, whereas complete resolution of portal vein thrombosis was observed 2 months later. A review of the literature is reported, and the possible pathogenetic mechanisms underlying portal vein thrombosis are discussed.
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| http://dx.doi.org/10.1016/j.jpedsurg.2007.03.052 | DOI Listing |
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