AI Article Synopsis
- Drugs of abuse, like alcohol, can lead to dependency and brain damage, affecting areas crucial for cognition.
- High-throughput technologies, including cDNA microarray and proteomics, are being used to analyze gene and protein expression in human brain tissue from substance abuse patients and animal models.
- Despite the limitations of current proteomics techniques, emerging studies are proposing new hypotheses to better understand the complexities of substance-related disorders.
Article Abstract
Drugs of abuse, including alcohol, can induce dependency formation and/or brain damage in brain regions important for cognition. 'High-throughput' approaches, such as cDNA microarray and proteomics, allow the analysis of global expression profiles of genes and proteins. These technologies have recently been applied to human brain tissue from patients with psychiatric illnesses, including substance abuse/dependence and appropriate animal models to help understand the causes and secondary effects of these complex disorders. Although these types of studies have been limited in number and by proteomics techniques that are still in their infancy, several interesting hypotheses have been proposed. Focusing on CNS proteomics, we aim to review and update current knowledge in this rapidly advancing area.
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| http://dx.doi.org/10.1586/14789450.4.4.539 | DOI Listing |
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