Aim: The aim of this study is to analyze the effect of apolipoprotein E (apo E) and methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms on serum lipid and homocysteine levels in the general Japanese population.
Methods: We analyzed the polymorphisms in individuals randomly selected from among participants of Serum Lipid Survey 2000.
Results: The frequency of the epsilon2, epsilon3, and epsilon4 alleles of APOE was 4.2, 85.3, and 10.5%, respectively. Individuals with the genotype epsilon4/epsilon4 had the highest total and low-density lipoprotein (LDL) cholesterol levels, while those with epsilon2/epsilon2 had the lowest. Individuals with the epsilon2/epsilon2 and epsilon2/epsilon4 genotypes had higher remnant-like particles (RLP)-cholesterol levels than those with epsilon2epsilon3, epsilon3epsilon3, and epsilon3epsilon4. There was a trend for individuals with the epsilon2/epsilon4 and epsilon2/epsilon2 genotypes to have higher triglyceride levels, although the difference was not significant. The presence of the T allele in a MTHFR polymorphism (C667T) was associated with higher homocysteine levels, which is more prominent in men than in women.
Conclusion: Thus in our large-scale analysis we have shown that RLP-cholesterol is better associated with, APOE genotype than triglyceride and the effect of the T allele on MTHFR polymorphism (C667T) homocysteine levels is more prominent in men than in women among Japanese.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.5551/jat.e499 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Evaluating the Clinical Impact of a Polyphenol-Rich Extract from on Patients with Transient Ischemic Attack and Minor Stroke.
Nutrients
December 2024
Instituto de Biomedicina de Sevilla, IBiS/Hospital Universitario Virgen Macarena/CSIC/Universidad de Sevilla, 41013 Seville, Spain.
Transient ischemic attack (TIA) is a well-established risk factor for future strokes, making interventions that target recovery and vascular risk crucial. This study aimed to assess the safety and clinical effects of a polyphenol-rich extract in post-TIA patients. A randomized, triple-blind, placebo-controlled trial was conducted with participants who had a history of TIA or minor stroke and who received 1 g of Salicornia extract or placebo over 11 months.
View Article and Find Full Text PDFGene Polymorphisms and DNA Methylation in Idiopathic Spontaneous Preterm Birth.
Medicina (Kaunas)
December 2024
Department of Medical Biology and Genetics, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia.
: Preterm birth (PTB) is a complex condition with various contributing factors, including genetic and epigenetic influences such as DNA methylation. Methylenetetrahydrofolate reductase (MTHFR) plays a critical role in DNA methylation and the remethylation of homocysteine. This study aimed to investigate the association between maternal MTHFR C677T and A1298C polymorphisms, LINE-1 DNA methylation levels, and the risk of idiopathic spontaneous preterm birth (SPTB) in Caucasian women from Croatia and Slovenia.
View Article and Find Full Text PDFEffect of Low- and High-Sulfur-Containing Amino Acid Inclusion in Diets Fed to Primiparous Sows in Late Gestation on Pre-Partum Nitrogen Retention and Offspring Pre- and Post-Weaning Growth Performance.
Animals (Basel)
December 2024
Department of Animal Science, South Dakota State University, Brookings, SD 57006, USA.
Twenty-seven gestating primiparous sows (203 ± 9.1 kg initial body weight on d 89 ± 1 of gestation) were selected to determine the effect of standardized ileal digestible (SID) sulfur-containing amino acid (SAA) intake during late gestation on whole-body nitrogen (N) retention and subsequent litter performance. Primiparous sows were assigned to one of two experimental diets that provided SAAs at 63 or 200% of the estimated requirements during late gestation (0.
View Article and Find Full Text PDFAnalysis of risk factors for abnormal renal function in patients with gout in Southwest China: a cross-sectional study.
Rheumatol Adv Pract
December 2024
Department of Rheumatology and Immunology, Clinical Medical College, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, PR China.
Objective: To analyse the associations between renal function and clinical laboratory indicators and explore the renal function abnormality risk factors for gout patients in Southwest China.
Methods: Outpatient and hospitalized gout patients ( = 4384) at the First Affiliated Hospital of Chengdu Medical College between January 2017 and December 2020 were divided into normal ( = 2393) and abnormal ( = 1991) renal function groups according to their eGFR. The relationships between clinical laboratory indicators and the eGFR were analysed, and a logistic regression model was fit to identify significant risk factors.
Effect of plasma homocysteine on cardiometabolic multimorbidity among Chinese adults: a population-based and real-world evidence study.
Front Nutr
December 2024
Clinical Epidemiology Research Office, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China.
Aims: To explore the effect of plasma homocysteine (Hcy) on cardiometabolic multimorbidity (CMM) among Chinses adults.
Methods: This study combined a community-based cross-sectional study with a 1:1 matched case-control study using propensity score method among adults aged over 30 years in six districts randomly selected from Hunan Province, China. We recruited 5,258 people, of whom 4,012 met the study criteria were enrolled.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!