Polysaccharide sulfate (PSS) is a new type of antiatherosclerotic medicine for its effects of anticoagulation, anti-thrombosis and modulation of dyslipidemia. However, it is still uncertain whether PSS could modulate the diabetic dyslipidemia or not. Here, the rat model of diabetic dyslipidemia was developed and the effects of PSS on glucose and lipid levels were investigated in this animal model. Wistar rats were iv injected with streptozotocin 20 mg x kg(-1) after feeding with high fat diet for one and a half month. Then, rats received orally PSS (30, 90, and 180 mg x kg(-1)) for 1 month. After oral treatment with PSS (90 and 180 mg x kg(-1)) for 1 month, the levels of triglyceride (TG), total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C) were significantly reduced and the level of high density lipoprotein-cholesterol (HDL-C) increased, compared with diabetic control rats. Moreover, PSS (30, 90, and 180 mg x kg(-1)) had a tendency to reduce glucose and insulin levels, and significantly increased insulin sensitivity index. Our results suggest that PSS could improve insulin sensitivity and relieve dyslipidemia in diabetic dyslipidemic rats.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Conjugated Polymer-Based Multilayer Thin-Film Triboelectric Nanogenerators via Continuous Layer-By-Layer Coating Process.
ACS Appl Mater Interfaces
January 2025
Department of Mechanical Engineering, Myongji University, 116 Myongji-ro, Cheoin-gu, Yongin, Gyeonggi-do 17058, Republic of Korea.
This study introduces a flexible and scalable charge-trapping intermediate layer of conjugated polymeric film comprising [PANI/PEDOT:PSS] between the [PVA/PDDA] triboelectric layer and graphene-based [PVA/GNP-PSS] electrode using the layer-by-layer (LbL) assembly method. By varying the deposition layers, the optimal coating layout was identified as 2 and 8 bilayers of intermediate and triboelectric layers, respectively. The triboelectric nanogenerator (TENG) fabricated with this optimal configuration achieved peak output voltage and current of 180 V and 9 μA, respectively, at 3 Hz and 5 N against PDMS.
View Article and Find Full Text PDFMeta-analysis of mortality-associated factors in primary Sjögren's syndrome patients with interstitial lung disease.
Clin Rheumatol
January 2025
Department of Rheumatology and Immunology, the Second Hospital of Hebei Medical University, No. 215, Heping West Road, Xinhua District, Shijiazhuang, 050000, Hebei Province, China.
The study aims to conduct a meta-analysis on 5-year survival rate and mortality-related factors in the patients with primary Sjögren's syndrome concomitant with interstitial lung disease (pSS-ILD). Following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, we searched various platforms and databases until November 22, 2023. We used the Newcastle-Ottawa Scale (NOS) for quality assessment and extracted study characteristics and effect sizes.
View Article and Find Full Text PDFThe intravenous administration of blood cell secretome can improve clinical signs in dogs with osteoarthritis.
Res Vet Sci
November 2024
Faculty of Veterinary Medicine, University of Lisbon (FMV/ULisboa) -, Lisbon, Portugal; Interdisciplinary Centre for Research in Animal Health (CIISA) - University of Lisbon, (FMV/ULisboa) - Lisbon, Portugal; Anjos of Assis Veterinary Medicine Centre (CMVAA), Barreiro, Portugal.
We aimed to evaluate the effect of the intravenous (IV) administration of blood cell secretome (BCS) compared to its intra-articular (IA) administration. In this cross-over study, ten dogs with bilateral hip osteoarthritis were initially assigned to an IA group (IAG). After a 180-day follow-up, the same 10 animals were assigned to an IV group (IVG).
View Article and Find Full Text PDFEmotional eating mediates the relationship between perceived stress and body appreciation in adult male and female: A cross-sectional study in Turkey.
Arch Psychiatr Nurs
October 2024
Ankara University Faculty of Health Sciences, Department of Nutrition and Dietetics, Ankara, Turkey. Electronic address:
The aim of this study was to investigate the association between adults' perceived stress, emotional eating, and body appreciation. The Emotional Eater Questionnaire (EES), the Perceived Stress Scale (PSS), and the Body Appreciation Scale-2 (BAS-2) were completed by 710 adult participants. Emotional eating was found to be adversely related to body appreciation in both female (=-0.
View Article and Find Full Text PDFSelf-medication in medical students in urban India: Exploring the extent of this dangerous practice.
J Family Med Prim Care
August 2024
Department of Pharmacology, K.J. Somaiya Medical College, Somaiya Ayurvihar Complex, Sion (E), Mumbai, Maharashtra, India.
Objectives: To assess the prevalence of self-medication in urban Indian medical students and explore possible factors associated with this practice.
Methods: After obtaining institutional ethics approval, 180 medical students from six medical colleges in Mumbai were recruited to participate via social media. They were administered a pre-validated questionnaire that assessed self-medication as a practice, along with the perceived stress scale (PSS-10) online.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!