AI Article Synopsis
- When nerve cells in the central nervous system (CNS) get injured, they usually can't grow back because the environment around them doesn't help and they're not very good at healing themselves.
- However, when peripheral nerves (which are outside the CNS) are injured, they can be made to grow better by using certain growth signals, like a chemical called GDNF.
- Researchers found that using the right amount of GDNF helps these injured nerves grow back more effectively, especially if the nerves were prepared beforehand, and too much GDNF isn't as helpful.
Article Abstract
Axonal regeneration within the CNS fails due to the growth inhibitory environment and the limited intrinsic growth capacity of injured neurons. Injury to DRG peripheral axons induces expression of growth associated genes including members of the glial-derived neurotrophic factor (GDNF) signaling pathway and "preconditions" the injured cells into an active growth state, enhancing growth of their centrally projecting axons. Here, we show that preconditioning DRG neurons prior to culturing increased neurite outgrowth, which was further enhanced by GDNF in a bell-shaped growth response curve. In vivo, GDNF delivered directly to DRG cell bodies facilitated the preconditioning effect, further enhancing axonal regeneration beyond spinal cord lesions. Consistent with the in vitro results, the in vivo effect was seen only at low GDNF concentrations. We conclude that peripheral nerve injury upregulates GDNF signaling pathway components and that exogenous GDNF treatment selectively promotes axonal growth of injury-primed sensory neurons in a concentration-dependent fashion.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2034440 | PMC |
| http://dx.doi.org/10.1016/j.mcn.2007.06.011 | DOI Listing |
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