Cytochrome c oxidase has been for a long time one of the central topics studied in Rome by Maurizio Brunori. The authors of this paper have had the unique opportunity of collaborating with him and his friends worldwide for many years. Among the very large number of papers on this enzyme produced by Maurizio Brunori, just a few have been selected here which are particularly representative for the three of us. Topics deal mostly with the interplay between the electrochemical potential gradient in its components and the electron transfer and the proton translocation reactions of this fascinating enzyme.
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Biol Direct
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Dipartimento di Scienze Biochimiche "A. Rossi Fanelli", Sapienza Università di Roma, Laboratory Affiliated to Istituto Pasteur Italia - Fondazione Cenci Bolognetti, 00185 Rome, Italy. Electronic address:
The funneled energy landscape theory suggests that the folding pathway of homologous proteins should converge at the late stages of folding. In this respect, proteins displaying a broad energy landscape for folding are particularly instructive, allowing inferring both the early, intermediate and late stages of folding. In this paper we explore the folding mechanisms of human frataxin, an essential mitochondrial protein linked to the neurodegenerative disorder Friedreich's ataxia.
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Biol Direct
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Presidente emerito Classe di Scienze FMN, Accademia Nazionale dei Lincei, e Professore emerito di Chimica e Biochimica, Dipartimento di Scienze Biochimiche, Sapienza Università di Roma, Rome, Italy.
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