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Assessment of the vascularity of uterine leiomyomas using double-echo dynamic perfusion-weighted MRI with the first-pass pharmacokinetic model: correlation with histopathology. | LitMetric
Objectives : To retrospectively evaluate the feasibility of perfusion-weighted MRI (PWI) in uterine leiomyomas.Materials And Methods : : Eighteen uterine leiomyomas in 15 patients were evaluated. PWI was performed using a double-echo T2*-weighted spoiled gradient-recalled acquisition sequence, and the first-pass pharmacokinetic model was applied to calculate relative blood volume (rBV). Histopathologic analysis was performed to measure vascular area (VA).Results : PWI was successful in 13 of 15 patients. On quantitative analysis, mean (+/-SD) rBV calculated from PWI was 0.17 +/- 0.13 (range, 0.06-0.55), whereas mean VA was 3.3% +/- 1.6% (range, 1.7-8.5%). A significant correlation was identified between rBV and VA (r = 0.87, P < 0.001).Conclusions : The rBV determined at PWI correlates with histologic vascular area in uterine leiomyomas.
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