Whether changes in renal blood flow (RBF) are associated with and possibly contribute to cystic disease progression in autosomal dominant polycystic kidney disease (ADPKD) has not been ascertained. The Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) was created to develop imaging techniques and analyses to evaluate progression. A total of 131 participants with early ADPKD had measurements of RBF and total kidney (TKV) and cyst (TCV) volumes by magnetic resonance and of GFR by iothalamate clearance at baseline and 1, 2, and 3 yr. The effects of age, gender, body mass index, hypertension status, mean arterial pressure (MAP), TKV, TCV, RBF, renal vascular resistance (RVR), GFR, serum uric acid, HDL and LDL cholesterol, 24-h urine volume, sodium (UNaE) and albumin (UAE) excretions, and estimated protein intake were examined at baseline on TKV, TCV, and GFR slopes. TKV and TCV increased, RBF decreased, and GFR remained stable. TKV, TCV, RVR, serum uric acid, UAE, UNaE, age, body mass index, MAP, and estimated protein intake were positively and RBF and GFR negatively correlated with TKV and TCV slopes. TKV, RBF, UNaE, and UAE were independent predictors of TKV and TCV slopes (structural disease progression). TKV, TCV, RVR, and MAP were negatively and RBF positively correlated with GFR slopes. Regression to the mean confounded the analysis of GFR slopes. TKV and RBF were independent predictors of GFR decline (functional disease progression). In ADPKD, RBF reduction (1) parallels TKV increase, (2) precedes GFR decline, and (3) predicts structural and functional disease progression.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2215/CJN.00910306 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Deep learning-based segmentation of kidneys and renal cysts on T2-weighted MRI from patients with autosomal dominant polycystic kidney disease.
Eur Radiol Exp
October 2024
Department of Urinary and Vascular Imaging, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France.
Article Synopsis
- The study aimed to create and evaluate a deep learning algorithm for automatically segmenting kidneys and renal cysts in patients with autosomal dominant polycystic kidney disease (ADPKD) using MRI scans.
- Researchers used a combination of historical MRI data and added normal renal scans to train the algorithm, comparing its results to those from human raters to measure accuracy.
- While the algorithm performed fairly well within the variability of human ratings, it tended to underestimate the total kidney and cyst volume, particularly in cases with very large cyst volumes.
The association of serum angiogenic growth factors with renal structure and function in patients with adult autosomal dominant polycystic kidney disease.
Int Urol Nephrol
July 2018
Division of Nephrology, Antalya Training and Research Hospital, Antalya, Turkey.
Article Synopsis
- The study investigates the relationship between specific serum angiogenic factors (Ang-1, Ang-2, and VEGF) and kidney health in adult patients with autosomal dominant polycystic kidney disease (ADPKD) at different stages of chronic kidney disease (CKD).
- It involved 50 ADPKD patients and a control group of 45 healthy individuals, examining kidney volume and functions through imaging and blood tests.
- The results indicated that while ADPKD patients had significant kidney volume and function changes, there was no correlation between the serum angiogenic factors and kidney health, suggesting Ang-2 might only play a role early in the disease progression.
Quantitative magnetic resonance imaging assessments of autosomal recessive polycystic kidney disease progression and response to therapy in an animal model.
Pediatr Res
May 2018
Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio.
BackgroundAutosomal recessive polycystic kidney disease (ARPKD) is associated with significant mortality and morbidity, and currently, there are no disease-specific treatments available for ARPKD patients. One major limitation in establishing new therapies for ARPKD is a lack of sensitive measures of kidney disease progression. Magnetic resonance imaging (MRI) can provide multiple quantitative assessments of the disease.
View Article and Find Full Text PDFNovel three-dimensional imaging volumetry in autosomal dominant polycystic kidney disease: comparison with 2D volumetry.
Clin Nephrol
August 2014
Department of Internal Medicine, Kangbuk Samsung Hospital, Department of Radiology, Sungkyunkwan University School of Medicine, Department of Internal Medicine, Eulji General Hospital, and Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Background: Autosomal dominant polycystic kidney disease (ADPKD) volumetry is an important marker for evaluating the progression of disease. Three-dimensional (3D) volumetry is generally more timesaving than 2D volumetry, but its reliability and accuracy are uncertain.
Methods: Small and large phantoms simulating polycystic kidneys and 20 patients with ADPKD underwent magnetic resonance imaging (MRI) volumetry.
Treatments to slow progression of autosomal dominant polycystic kidney disease: systematic review and meta-analysis of randomized trials.
Nephrology (Carlton)
April 2014
Department of Renal Medicine and Transplantation, Westmead Hospital, Western Sydney Local Health District, Sydney, New South Wales, Australia.
Aim: Autosomal dominant polycystic kidney disease (ADPKD) is a monogenetic disorder that leads to kidney failure. Our aim was to undertake a meta-analysis of randomized trials of interventions that have been hypothesized to reduce the progression of total kidney volume (TKV) and renal function in ADPKD.
Methods: Relevant trials were identified, and outcomes were: change in TKV, total cyst volume (TCV), renal function and adverse events.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!