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Sequence analysis of the Staphylococcus aureus srrAB loci reveals that truncation of srrA affects growth and virulence factor expression. | LitMetric
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Sequence analysis of the Staphylococcus aureus srrAB loci reveals that truncation of srrA affects growth and virulence factor expression.

Alexa A Pragman Lisa Herron-Olson Laura C Case Sara M Vetter Evan E Henke Vivek Kapur Patrick M Schlievert

J Bacteriol

Department of Microbiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.

Published: October 2007

The SrrAB system regulates metabolism and virulence factors in Staphylococcus aureus. We sequenced the srrAB loci of 21 isolates and performed a phylogenetic analysis. Vaginal and bovine isolates clustered together, while skin isolates were genetically diverse. Few nucleotide polymorphisms were observed, and most were synonymous. Two strains (N2 and N19) with N-terminal truncations in SrrA displayed defects in growth and abnormally upregulated virulence factor expression under low-oxygen conditions.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2168425PMC
http://dx.doi.org/10.1128/JB.00547-07DOI Listing

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