AI Article Synopsis
- Abacavir is mainly metabolized by two enzymes: alcohol dehydrogenase and gluconyl transferase.
- Normally, alcohol is broken down in the liver into acetaldehyde and then into acetic acid, but disulfiram can block the enzyme that converts acetaldehyde to acetic acid.
- There's a possibility that abacavir can inhibit alcohol dehydrogenase, potentially leading to disulfiram-like reactions or reduced tolerance to alcohol during abacavir treatment.
Article Abstract
Abacavir is metabolized primarily by two enzymes: alcohol dehydrogenase and gluconyl transferase. Under normal conditions, alcohol is hepatically cleared via alcohol dehydrogenase to acetaldehyde, and subsequently by acetaldehyde dehydrogenase (ACD) to acetic acid. Disulfiram acts as an ACD blocker. Abacavir may also act as an inhibitor of alcohol dehydrogenase, which raises the possibility of disulfiram-like reactions (if complete inhibition occurs) or reduced alcohol tolerance (if partial inhibition occurs) occurring with abacavir therapy.
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| http://dx.doi.org/10.1097/QAD.0b013e328270b88d | DOI Listing |
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