An abnormal isoform of the prion protein, associated with transmissible spongiform encephalopathies, retains infectivity even after undergoing routine sterilization processes. We found that a formulation of iron ions combined with hydrogen peroxide effectively reduced infectivity and the level of abnormal isoforms of the prion protein in scrapie-infected brain homogenates. Therefore, the Fenton reaction has potential for prion decontamination.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1271/bbb.70085 | DOI Listing |
ACS Appl Mater Interfaces
January 2025
State Key Laboratory of Separation Membranes and Membrane Processes, Tiangong University, Tianjin 300387, PR China.
The photo-Fenton reaction can efficiently degrade organic pollutants and thus is applied intensively for clearing out membrane fouling. However, the pollutant removal efficiency is greatly limited by the redox cycle rate of Fe/Fe and the rapid recombination rate of the photogenerated electrons and holes. In order to overcome these drawbacks, a sulfonated polysulfone composite membrane was designed and prepared by incorporating titanium dioxide (TiO) nanoparticles into a sulfonated polysulfone membrane and sequentially forming β-FeOOHs on the membrane surface.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
Department of Gastroenterology, Changhai Hospital, Naval Medical University, No. 168 Changhai Road, Shanghai 200433, PR China. Electronic address:
In this paper, a pH-sensitive chitosan-grafted phenylboronic acid (CS-BA)/polyvinyl alcohol (PVA) hydrogel was constructed based on dynamic borate bonding for loading chemotherapeutic drug cisplatin (CDDP) and divalent Cu (CS-BA/PVA-Cu-CDDP). The hydrogel can respond and degrade specifically in the simulative acidic tumor microenvironment (TME), and the released Cu can deplete glutathione (GSH) in tumor cells and generate Cu. It is worth noting that, Cu can further catalyze the Fenton-like reaction to generate cancer cell-toxic hydroxyl radicals (OH•).
View Article and Find Full Text PDFTheranostics
January 2025
Bionanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Republic of Korea.
Activatable multifunctional nanoparticles present considerable advantages in cancer treatment by integrating both diagnostic and therapeutic functionalities into a single platform. These nanoparticles can be precisely engineered to selectively target cancer cells, thereby reducing the risk of damage to healthy tissues. Once localized at the target site, they can be activated by external stimuli such as light, pH changes, or specific enzymes, enabling precise control over the release of therapeutic agents or the initiation of therapeutic effects.
View Article and Find Full Text PDFChem Commun (Camb)
January 2025
College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University, Jinan 250014, P. R. China.
Herein, we report a nanoscale composite COF material loaded with copper peroxide (CuO) and nitric oxide (NO) prodrug a stepwise post-synthetic modification. The obtained CuO2@COF-SNO can undergo a cascade reaction in the tumor microenvironment to generate reactive oxygen and nitrogen species (ROS/RNS) to enhance chemodynamic therapy of the tumor.
View Article and Find Full Text PDFSci Adv
January 2025
CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China.
Chemodynamic therapy (CDT) is a promising and potent therapeutic strategy for the treatment of cancer. We developed a DNA origami-based enzymatic cascade nanoreactor (DOECN) containing spatially well-organized Au nanoparticles and ferric oxide (FeO) nanoclusters for targeted delivery and inhibition of tumor cell growth. The DOECN can synergistically promote the generation of hydrogen peroxide (HO), consumption of glutathione, and creation of an acidic environment, thereby amplifying the Fenton-type reaction and producing abundant reactive oxygen species, such as hydroxyl radicals (•OH), for augmenting the CDT outcome.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!