Background: Endurance training is an effective component of pulmonary rehabilitation in COPD. Controversy exists regarding whether different modalities of supervised exercise training (continuous (C) or interval (I)) or self-paced (S) programs are equally beneficial.
Methods: Seventy-one patients with COPD (average FEV(1)=55% predicted) were assigned to 8 weeks of C, I or S training, 45 min/session, 3 times/week. Group C (n=22) exercised at 80% of pre-training peak work rate in an incremental cycle ergometer test. In group I (n=17), training consisted of 30 min of cycling 2 min at 90% followed by 1 min at 50% peak work rate bracketed by 7.5 min at 50% peak work rate. The S group (n=32) was instructed to cycle, climb stairs and walk in their home with the same periodicity and time intervals.
Results: Improvement in incremental test peak work rate was significant in both C and I groups, but not in S. Peak oxygen uptake and lactic acidosis threshold improved significantly in the supervised groups, but differences among groups did not achieve significance. Scores in an activity questionnaire improved in all groups without significant differences among groups.
Conclusions: In COPD patients, continuous and interval training have similar physiologic effects; by some measures of endurance exercise performance, they are superior to self-paced training. However, all were effective in improving patient-perceived activity.
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http://dx.doi.org/10.1016/j.rmed.2007.06.017 | DOI Listing |
Front Pharmacol
January 2025
Department of Biology, Mardin Artuklu University Graduate Education Institute, Mardin, Türkiye.
Interest in metal nanoparticles synthesised using green methods is growing steadily. Metal nanoparticles can be synthesised inexpensively and effortlessly using extracts derived from different plants and their diverse components. Gold nanoparticles (Au NPs) were rapidly synthesised from Broccoli ( L.
View Article and Find Full Text PDFHeliyon
January 2025
Department of Pediatrics, The First People's Hospital of Yunnan Province, Medical School & Affiliated Hospital, Kunming University of Science and Technology, Kunming, Yunnan, China.
Background: The drug nusinersen is applied to improve motor function in patients with spinal muscle atrophy (SMA). However, research on the effects of this treatment on lung function is lacking.
Aim: To investigate the effect of nusinersen on lung function in children with SMA in the Plateau.
Analyst
January 2025
Department of Fundamental Chemistry, Institute of Chemistry, University of São Paulo, São Paulo, SP, 05508-000, Brazil.
The development of a print-at-home, low-cost, and miniaturized paper-based cell with 3D-printed electrodes using a 3D-printing pen and a bespoke conductive filament for detecting capsaicin in hot sauce is reported herein. The material cost of producing each electrode was less than £0.01.
View Article and Find Full Text PDFAnal Chim Acta
February 2025
Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University) Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing, PR China. Electronic address:
Background: Sensitive and accurate detection of important cancer markers MicroRNAs (miRNAs) is critical to prevent and treat disease. Among many detection techniques, surface-enhanced Raman scattering(SERS) has attracted much attention due to its advantages such as narrow spectral peak, low interference and non-destructive detection. Interestingly, non-noble metal SERS substrates show good prospects due to their outstanding spectral reproducibility and biocompatibility.
View Article and Find Full Text PDFAnal Chim Acta
February 2025
Department of Analytical Chemistry, Faculty of Chemistry, Universitat de València, C/ Dr. Moliner 50, 46100, Burjassot, Spain. Electronic address:
Background: Developing analytical methods for Traditional Medicine products by liquid chromatography is challenging due to their chemical complexity and the lack of analytical standards for numerous, unidentified constituents. Regulatory agencies recommend chromatographic fingerprint analysis for quality evaluation, relying on peak detection to ensure resolution. Conventional modelling struggles to optimise experimental conditions for such complex samples.
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