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Soft Tissue Tumor with Kinase Fusion: An Emerging Sarcoma Entity.
Case Rep Oncol
August 2024
Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden.
Introduction: Here, we report the first case of a soft tissue tumor with a fusion.
Case Presentation: The patient was an 11-year-old female presenting with a 5 cm intramuscular mass in the lower leg. Microscopic examination revealed a mitotically active spindle cell lesion with monomorphic and moderately atypical cells growing in a patternless pattern with the presence of stromal and perivascular keloidal collagen with focal immunoreactivity for smooth muscle actin and S100; negative stains included cytokeratins, CD34, and caldesmon.
The role of IL-17 and Th17 cells in keloid pathogenesis.
Arch Dermatol Res
September 2024
Dermatology Service, Veterans Affairs New York Harbor Healthcare System - Brooklyn Campus, Brooklyn, NY, USA.
Keloids are characterized histologically by excessive fibroblast proliferation and connective tissue deposition, and clinically by scar tissue extending beyond the original site of skin injury. These scars can cause pruritus, pain, physical disfigurement, anxiety, and depression. As a result, keloid patients often have a diminished quality of life with a disproportionate burden on ethnic minorities.
View Article and Find Full Text PDFSystematic review of dupilumab safety and efficacy for treatment of keloid scars.
Arch Dermatol Res
August 2024
Dermatology Service, Veterans Affairs New York Harbor Healthcare System, Brooklyn Campus, Brooklyn, NY, USA.
Keloids, characterized by excessive scar formation following dermal inflammation, pose a therapeutic challenge due to high recurrence rates. Radiation therapy, contraindicated in children, can minimize recurrence post-surgical removal. Dupilumab, which inhibits the pro-fibrotic interleukin-4/interleukin-13 axis, may effectively manage keloids when intralesional corticosteroid injections are unsuccessful.
View Article and Find Full Text PDFmiRSNP rs188493331: A key player in genetic control of microRNA-induced pathway activation in hypertrophic scars and keloids.
Skin Res Technol
May 2024
Department of Plastic and Reconstructive Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Article Synopsis
- The study explores the interactions between miRSNPs, microRNAs, genes, and pathways related to hypertrophic scars and keloids.
- It performs differential expression analysis and bioinformatics to identify key hub genes and their roles in specific signaling pathways like TGF-β and PI3K/Akt.
- The findings highlight important microRNAs, particularly miRNA-1279 and miRNA-429, and their significant control over gene regulation, revealing how these interactions contribute to scar formation.
An analysis of keloid patient questions on Reddit.
Wound Repair Regen
March 2024
Department of Dermatology, State University of New York, Downstate Health Sciences University, Brooklyn, New York, USA.
Reddit is one of the world's leading social media platforms, fostering active community discussions on a variety of topics including keloids. The prevalence and reach of conversations on Reddit underscore the need to investigate and understand patient perspectives and gaps in knowledge. Herein, we present an in-depth analysis of questions and concerns of Reddit users on keloids, offering valuable insights into patient experiences, knowledge gaps and treatment preferences.
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