Background: Gastroesophageal reflux (GER) and coronary artery disease (CAD) frequently overlap, making the proper diagnosis of chest pain more difficult. GER symptoms may mistake anginal chest pain, and oesophageal acidification may induce myocardial ischaemia both in the rest and in the effort. Increase of oesophageal pH should prevent these conditions.
Aim: To estimate the effect of double omeprazole dose on the course of angina pectoris and treadmill stress test in patients with coronary artery disease (CAD), using double-blind, crossover randomised, placebo-controlled study design.
Methods: We studied 48 patients with angina pectoris symptoms and significant narrowing of coronary vessels in angiography. After baseline examination and treadmill stress test all subjects were randomised to treat either with omeprazole (20 mg b.i.d.) or placebo for 14 days, using a double-blind, crossover placebo controlled design.
Results: Seventeen (35%) subjects reported more than by half decrease in symptoms severity after omeprazole and 6 (12%) after placebo (p=0,01). Omeprazole significantly decreased the number of chest pain episodes and number of nitroglycerin doses taken in the second week of both study phases, as well as the percentage of subjects with significant decrease of ST interval during the stress test (64% vs. 73%, p<0,05). However majority of other stress test parameters (i.e. test duration, DUKE index) have improved both after omeprazole and placebo administration (by 9-38%).
Conclusion: Double dose of omeprazole significantly decreased symptoms severity in 35% of patients with CAD, as well as frequency of some electrocardiographic signs of myocardial ischaemia during stress test.
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http://dx.doi.org/10.1016/j.ijcard.2007.04.079 | DOI Listing |
JMIR Ment Health
January 2025
Center for Psychotraumatology, Institute of Psychology, Vilnius University, Vilnius, Lithuania.
Background: Prompts offer a promising strategy to promote client engagement in internet-delivered cognitive behavioral therapy (ICBT). However, if the prompts do not meet the needs of clients, they can potentially be more obtrusive rather than helpful.
Objective: The aim of this study was to test if prompts tailored based on timing and frequency, aligned with preintervention goal setting, can increase usage and the efficacy of a therapist-supported ICBT stress recovery intervention for health care workers.
J Strength Cond Res
February 2025
Sports Medicine and Movement Laboratory, School of Kinesiology, Auburn University, Auburn Alabama.
Bordelon, NM, Agee, TW, Wasserberger, KW, Downs-Talmage, JL, Everhart, KM, and Oliver, GD. Field-testing measures related to youth baseball hitting performance. J Strength Cond Res 39(2): 210-216, 2025-The purpose of the study was to determine the relationship between field tests and youth hitting performance (batted-ball velocity).
View Article and Find Full Text PDFWiad Lek
January 2025
MUNICIPAL NONPROFIT ENTERPRISE «TERNOPIL REGIONAL CLINICAL HOSPITAL», TERNOPIL REGIONAL RADA, TERNOPIL, UKRAINE.
Objective: Aim: To study the ATFL length among asymptomatic population of young patients on both joints by using the method of ultrasound examination of the ankle joint and applying the inversion stress test.
Patients And Methods: Materials and Methods: the length of the ATFL was measured among 60 boys and 60 girls during the research. Sonography was performed on both joints, in each of the two studied positions, three times per position in order to obtain the average ligament length.
Med Biol Eng Comput
January 2025
Department of Orthopaedics, School of Medicine, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China.
Finite element analysis has become indispensable for biomechanical research on clavicle fractures. This review summarized evidence regarding configurations and applications of finite element analysis in clavicle fracture fixation. Seventeen articles involving 22 clavicles were synthesized from CINAHL, Embase, IEEE Xplore, PubMed, Scopus, and Web of Science databases.
View Article and Find Full Text PDFNaunyn Schmiedebergs Arch Pharmacol
January 2025
Department of Pharmacology, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria.
Stress is linked to oxidative imbalance, neuroendocrine system malfunction, and cognitive dysfunction. It is a recognized cause of neuropsychiatric diseases. Natural flavonoid apigenin (API) has neuroprotective and antidepressant properties, but little is known about its potential in restoring memory function under stress-related circumstances.
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