AI Article Synopsis

  • The study investigates the impact of double doses of omeprazole on angina symptoms and treadmill stress tests in patients with coronary artery disease (CAD).
  • Results indicated that 35% of participants experienced a significant reduction in symptoms with omeprazole compared to only 12% with placebo, highlighting its effectiveness in decreasing chest pain episodes.
  • The findings suggest omeprazole may help alleviate symptoms of both GER and CAD by reducing myocardial ischemia signs during stress tests.

Article Abstract

Background: Gastroesophageal reflux (GER) and coronary artery disease (CAD) frequently overlap, making the proper diagnosis of chest pain more difficult. GER symptoms may mistake anginal chest pain, and oesophageal acidification may induce myocardial ischaemia both in the rest and in the effort. Increase of oesophageal pH should prevent these conditions.

Aim: To estimate the effect of double omeprazole dose on the course of angina pectoris and treadmill stress test in patients with coronary artery disease (CAD), using double-blind, crossover randomised, placebo-controlled study design.

Methods: We studied 48 patients with angina pectoris symptoms and significant narrowing of coronary vessels in angiography. After baseline examination and treadmill stress test all subjects were randomised to treat either with omeprazole (20 mg b.i.d.) or placebo for 14 days, using a double-blind, crossover placebo controlled design.

Results: Seventeen (35%) subjects reported more than by half decrease in symptoms severity after omeprazole and 6 (12%) after placebo (p=0,01). Omeprazole significantly decreased the number of chest pain episodes and number of nitroglycerin doses taken in the second week of both study phases, as well as the percentage of subjects with significant decrease of ST interval during the stress test (64% vs. 73%, p<0,05). However majority of other stress test parameters (i.e. test duration, DUKE index) have improved both after omeprazole and placebo administration (by 9-38%).

Conclusion: Double dose of omeprazole significantly decreased symptoms severity in 35% of patients with CAD, as well as frequency of some electrocardiographic signs of myocardial ischaemia during stress test.

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Source
http://dx.doi.org/10.1016/j.ijcard.2007.04.079DOI Listing

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