AI Article Synopsis
- The study assessed how the status of conization margins affects outcomes in patients with cervical adenocarcinoma in situ (AIS) over a nearly two-decade period.
- A total of 74 patients were reviewed, revealing that 30% had positive margins, which was associated with a high risk of residual or recurrent disease compared to those with negative margins.
- The findings underline that even when conization margins are negative, there remains a significant risk of disease recurrence or progression, highlighting the importance of ongoing monitoring.
Article Abstract
Objective: We evaluated the impact of conization margin status on outcomes of patients diagnosed with cervical adenocarcinoma in situ.
Study Design: A retrospective chart review identified patients at a University hospital from 1988-2006 with adenocarcinoma in situ (AIS) on conization.
Results: Seventy-four patients were included. Median follow-up was 26 months. Twenty-two of 74 patients (30%) had positive margins, 46 patients (62%) had negative margins, and 6 patients had indeterminate margins. Of patients with positive margins, 55% (12/22) were diagnosed with residual or recurrent disease, including 3 patients diagnosed with adenocarcinoma on hysterectomy. Thirteen percent of patients with negative conization margins (6/46) were diagnosed with residual or recurrent disease, including 2 patients diagnosed with adenocarcinoma during follow-up. Cold knife conization resulted in a significantly higher number of negative margins compared to other conization procedures (P = .013).
Conclusions: Even with negative conization margins, women still face a risk of residual, recurrent, or invasive disease.
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| http://dx.doi.org/10.1016/j.ajog.2007.04.035 | DOI Listing |
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