We present in this work a descriptive study of series of cases in treatment for nicotine addiction with a multicomponent program focusing on a systemic-relational therapy. While a good number of smokers are able to stop smoking, with the help of different programs with different levels of complexity depending on their level of addiction, there is a group of smokers who associate their difficulty to stop smoking with aspects related to their life cycle situation, problems with their family of origin or with their social network. We revised the most relevant clinical aspects of the model and presented the results of a descriptive study of a series of 128 patients, of wich 60.50% expressed family and/or personal problems that made the possibilities of success in the program more difficult. After an intervention that lasted a year during wich there were 25 therapy sessions together with combined substitute therapy with nicotine (STN) during the first 3 months of treatment, 77.30% maintained abstinence. Nowadays we know much more about nicotine addictions, giving different answers to different needs, just like the different levels of complexity of each addict. We consider that the contributions of the systemic-relational model in its different ways of understanding the intervention, can better the results of the treatment. We are justified in increasing the level of complexity of the interventions when there exist complications in the clinical handling of nicotine addiction because of other models of treatment of lesser intensity.

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