Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/ja071427+ | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Upconversion Nanoparticle-Anchored Metal-Organic Framework Nanostructures for Remote-Controlled Cancer Optogenetic Therapy.
J Am Chem Soc
December 2024
School of Chemistry, Chemical Engineering, and Biotechnology, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore.
Optogenetics, a revolutionary technique utilizing light-sensitive proteins to control cellular functions with high spatiotemporal precision, presents a promising avenue for disease treatment; however, its application in cancer therapy remains constrained by limited research. Herein, we introduce a pioneering strategy for remote-controlled optogenetic cancer therapy, synergistically merging optogenetics with ion therapy, which incorporates ion self-supply, in situ ion channel construction, and near-infrared (NIR) light-activated ion therapy, facilitating remote and noninvasive manipulation of cellular activities in deep tissues and living animals. We report the facile synthesis of water-dispersible upconversion nanoparticle (UCNP)-metal-organic framework (MOF) nanohybrids capable of effectively delivering plasmid DNA to cancer cells, thereby enabling the in situ expression of photoactivatable cation channels.
View Article and Find Full Text PDFIn Vivo Optogenetics Based on Heavy Metal-Free Photon Upconversion Nanoparticles.
Adv Mater
November 2024
Department of Applied Chemistry, Graduate School of Engineering and Center for Molecular Systems (CMS), Kyushu University, 744 Moto-oka, Nishi-ku, Fukuoka, 819-0395, Japan.
Photon upconversion (UC) from red or near-infrared (NIR) light to blue light is promising for in vivo optogenetics. However, the examples of in vivo optogenetics have been limited to lanthanide inorganic UC nanoparticles, and there have been no examples of optogenetics without using heavy metals. Here the first example of in vivo optogenetics using biocompatible heavy metal-free TTA-UC nanoemulsions is shown.
View Article and Find Full Text PDFFluoropolymer-Gadolinium(III) Hybrids for Photoactivatable Dual-Mode -Weighted H MRI and F MRI Contrast Agents.
ACS Macro Lett
October 2024
Key Laboratory of Rubber-plastics, Ministry of Education, School of Polymer Science and Engineering, Qingdao University of Science and Technology, Zhengzhou Rd. 53, CN-266042 Qingdao, China.
Multimodal imaging probes play a crucial role in overcoming the limitations associated with single-mode imaging for clinical medical diagnosis. This study focuses on the development of a photoresponsive fluorine-containing water-soluble polymer () through RAFT polymerization. Subsequently, a polymer-gadolinium(III) hybrid () dual-modal probe capable of -weighted H MRI and F MRI was synthesized via postmodification of with a Gd-DOTA derivative.
View Article and Find Full Text PDFElucidating and Optimizing the Photochemical Mechanism of Coumarin-Caged Tertiary Amines.
J Am Chem Soc
July 2024
Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147, United States.
Photoactivatable or "caged" pharmacological agents combine the high spatiotemporal specificity of light application with the molecular specificity of drugs. A key factor in all optopharmacology experiments is the mechanism of uncaging, which dictates the photochemical quantum yield and determines the byproducts produced by the light-driven chemical reaction. In previous work, we demonstrated that coumarin-based photolabile groups could be used to cage tertiary amine drugs as quaternary ammonium salts.
View Article and Find Full Text PDFPhotoactivatable Ruthenium Complexes Containing Minimal Straining Benzothiazolyl-1,2,3-triazole Chelators for Cancer Treatment.
Inorg Chem
April 2024
Departamento de Química Inorgánica, Universidad de Murcia and Biomedical Research Institute of Murcia (IMIB-Arrixaca), E-30100 Murcia, Spain.
Ruthenium(II) complexes containing diimine ligands have contributed to the development of agents for photoactivated chemotherapy. Several approaches have been used to obtain photolabile Ru(II) complexes. The two most explored have been the use of monodentate ligands and the incorporation of steric effects between the bidentate ligands and the Ru(II).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!