Vancomycin dispositions in the respiratory system were compared after systemic and inhalatory administration under two respiratory conditions using the isolated-lung model. Inhalatory delivery led to much higher drug levels in pulmonary tissue and fluids. The respiratory pattern affects vancomycin disposition in the pulmonary system regardless of the administration route.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2043261 | PMC |
| http://dx.doi.org/10.1128/AAC.00099-07 | DOI Listing |
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