In this work the capability of Progesterone (Prog) to penetrate to phosphatidyl serine (PS) monolayers (detected by equilibrium and dynamic surface tensions) and to induce rupture of PS thin liquid films (TLFs, known as foam films) in presence of Ca(2+) ions is studied. TLF studies reveal that the presence of Ca(2+) ions changes the type of PS films from thicker common black films to bilayer Newton black films and that the addition of Prog results in film destabilization and rupture. The effects of Prog in presence of Ca(2+) ions were observed with the films consisting of negatively charged PS but not of neutral phospholipids. The results correlate with the proposed physiological role of Prog and Ca(2+) in the acrosome reaction. The model of TLFs is used for the first time to study membrane fusion during acrosome reaction and proposes several new qualitative and quantitative parameters for studying of this reaction.
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| http://dx.doi.org/10.1016/j.bpc.2007.07.002 | DOI Listing |
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