AI Article Synopsis
- The study examined prolactin-releasing peptide (PrRP) mRNA levels in the hypothalamus and brainstem of diabetic rats induced by streptozotocin (STZ) and fa/fa Zucker rats using specialized techniques.
- PrRP mRNA levels were found to be significantly lower in STZ-induced diabetic rats compared to control rats, but increased with insulin and leptin treatment.
- Restraint stress elevated PrRP mRNA levels in both control and STZ-induced diabetic rats, suggesting that diabetes and insulin treatment influence PrRP expression regulations without impairing its role in stress responses.
Article Abstract
We investigated the prolactin-releasing peptide (PrRP) mRNA levels in the hypothalamus and brainstem of streptozotocin (STZ)-induced diabetic rats and fa/fa Zucker diabetic rats, using in situ hybridization histochemistry. PrRP mRNA levels in the hypothalamus and brainstem of STZ-induced diabetic rats were significantly reduced in comparison with those of control rats. PrRP mRNA levels in the diabetic rats were reversed by both insulin and leptin. PrRP mRNA levels in the fa/fa diabetic rats were significantly reduced in comparison with those of Fa/? rats. PrRP mRNA levels in the fa/fa diabetic rats were significantly increased by insulin-treatment, but did not reach control levels in the Fa/? rats. We also investigated the effect of restraint stress on PrRP mRNA levels in STZ-induced diabetic rats. The PrRP mRNA levels in the control and the STZ-induced diabetic rats increased significantly after restraint stress. The diabetic condition and insulin-treatment may affect the regulation of PrRP gene expression via leptin and other factors, such as plasma glucose level. The diabetic condition may not impair the role of PrRP as a stress mediator.
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| http://dx.doi.org/10.1016/j.peptides.2007.06.023 | DOI Listing |
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