Octa-O-bis-(R,R)-Tartarate Ditellurane (SAS) is a new Te(IV) compound, comprised of two tellurium atoms, each liganded by four oxygen atoms from two carboxylates and two alkoxides of two tartaric acids. Unlike many other Te(IV) compounds, SAS was highly stable in aqueous solution. It interacted with thiols to form an unstable Te(SR)(4) product. The product of the interaction of SAS with cysteine was isolated and characterized by mass spectroscopy and elemental analysis. SAS selectively inactivated cysteine proteases, but it did not inactivate other families of proteolytic enzymes. It displayed selectivity towards the cysteine protease cathepsin B, a human enzyme of pharmaceutical interest, with a second order rate constant k(i)/K(i)=5900 M(-1) s(-1).
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View Article and Find Full Text PDFThe small tellurium-based compound SAS suppresses inflammation in human retinal pigment epithelium.
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C.A.I.R. Institute, The Safdié AIDS and Immunology Research Center, The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel.
Article Synopsis
- Pathological angiogenesis and chronic inflammation are key factors in the development of choroidal neovascularization (CNV) in eye diseases, prompting a study on the effects of a compound called SAS on retinal pigment epithelial (RPE) cells.
- SAS was demonstrated to inhibit specific integrins on RPE cells, enhance the expression of protective factors such as PEDF, and significantly reduce inflammatory gene expression linked to angiogenesis when RPE cells were co-cultured with endothelial cells.
- The findings indicate that SAS could serve as an effective anti-inflammatory treatment for chorioretinal conditions, potentially improving therapeutic strategies in managing these diseases.
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The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, 5290002, Ramat Gan, Israel.
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