We investigate polymer translocation through a nanopore under a pulling force using Langevin dynamics simulations. We concentrate on the influence of the chain length N and the pulling force F on the translocation time tau . The distribution of tau is symmetric and narrow for strong F . We find that tau approximately N{2} and translocation velocity v approximately N{-1} for both moderate and strong F . For infinitely wide pores, three regimes are observed for tau as a function of F . With increasing F , tau is independent of F for weak F , and then tau approximately F{-2+nu{-1}} for moderate F, where nu is the Flory exponent, which finally crosses over to tau approximately F{-1} for strong force. For narrow pores, even for moderate force tau approximately F{-1}. Finally, the waiting time, for monomer s and monomer s+1 to exit the pore, has a maximum for s close to the end of the chain, in contrast to the case where the polymer is driven by an external force within the pore.
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http://dx.doi.org/10.1103/PhysRevE.75.061912 | DOI Listing |
Front Bioeng Biotechnol
January 2025
Department of Sports Medicine, The Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine (FJTCM), Fuzhou, China.
Humerus greater tuberosity (HGT) avulsion fracture is one of the most common types of proximal humerus fractures. The presence of motion and gap lead to the failure of implants, due to the force pulling from the supraspinatus. In this work, electrospinning technology was applied to fabricate PCL-PEG/CS/AST nanofiber with superior biocompatibility and mechanical property.
View Article and Find Full Text PDFBiophys J
January 2025
Department of Chemical Engineering, Columbia University, New York, NY 10027. Electronic address:
Membrane fusion is central to fundamental cellular processes such as exocytosis, when an intracellular machinery fuses membrane-enclosed vesicles to the plasma membrane for contents release. The core machinery components are the SNARE proteins. SNARE complexation pulls the membranes together, but the fusion mechanism remains unclear.
View Article and Find Full Text PDFJBJS Essent Surg Tech
January 2025
Department of Neurosurgery, Center for Neuroscience and Spine, Virginia Mason Medical Center, Seattle, Washington.
Background: Prone transpsoas lumbar interbody fusion (PTP) is a newer technique to treat various spinal disc pathologies. PTP is a variation of lateral lumbar interbody fusion (LLIF) that is performed with the patient prone rather than in the lateral decubitus position. This approach offers similar benefits of lateral spinal surgery, which include less blood loss, shorter hospital stay, and quicker recovery compared with traditional open spine surgery.
View Article and Find Full Text PDFBiomed Tech (Berl)
January 2025
Oral Technology, University of Bonn, Bonn, Germany.
Objectives: The aim of the present study was to investigate, whether polyetherketoneketone (PEKK) secondary crowns could be considered as alternative to gold standard in terms of their physical properties and manufacturing costs.
Methods: An upper jaw model with six implants was used. Frameworks with either 6 PEKK- or 6 electroplated secondary crowns were cemented in a wear simulator.
Langmuir
January 2025
Institute of Advanced Manufacturing Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Changzhou 213164, People's Republic of China.
Thermoresponsive shape memory polymer (SMP) adhesives have demonstrated a high adhesion strength and large switching ratios on different substrates. However, a long response time to switch adhesion on or off is generally encountered. This study provides a fast adhesion switching method based on the temperature and rate dependence of adhesion within the glass-transition zone of an epoxy polymer.
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