We study the effectiveness of recovery strategies for a dynamic model of failure spreading in networks. These strategies control the distribution of resources based on information about the current network state and network topology. In order to assess their success, we have performed a series of simulation experiments. The considered parameters of these experiments are the network topology, the response time delay, and the overall disposition of resources. Our investigations are focused on the comparison of strategies for different scenarios and the determination of the most appropriate strategy. The importance of prompt response and the minimum sufficient quantity of resources are discussed as well.
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http://dx.doi.org/10.1103/PhysRevE.75.056107 | DOI Listing |
Nucleic Acids Res
January 2025
State Key Laboratory of Cellular Stress Biology, Xiang'an Hospital, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, No. 4221, Xiang'an South Road, Xiamen, Fujian 361102, China.
Enhancer clusters, pivotal in mammalian development and diseases, can organize as enhancer networks to control cell identity and disease genes; however, the underlying mechanism remains largely unexplored. Here, we introduce eNet 2.0, a comprehensive tool for enhancer networks analysis during development and diseases based on single-cell chromatin accessibility data.
View Article and Find Full Text PDFChem Asian J
January 2025
Qingdao University of Science and Technology, College of Polymer Science and Engineering, 53 ZHENGZHOU ROAD, 266000, Qingdao, CHINA.
Constructing highly conjugated three-dimensional covalent organic frameworks (3D COFs), particularly those with luminescent features, remains a significant challenge. In this work, we successfully synthesized a 3D COF, named 3D-Py-SP-COF, using a rigid and orthogonal spirobifluorene building block for the spatial 3D structure construction and planar pyrene as luminescent units. The incorporation of the pyrene and the unique rigid 3D network structure endow 3D-Py-SP-COF with fluorescent properties.
View Article and Find Full Text PDFISA Trans
January 2025
School of Information Science and Engineering, Chengdu University, Chengdu, 610106, PR China. Electronic address:
This article addresses the secure synchronization problem for complex dynamical networks (CDNs) with observer-based event-triggered communication strategy (ETCS) under multi-channel denial-of-service attacks (MCDSAs). Due to external environmental interference, the observers are designed to accurately estimate the state of the network systems. Meanwhile, the impact of cyber attacks on system security is considered.
View Article and Find Full Text PDFNeurobiol Dis
January 2025
Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China; National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China. Electronic address:
Background: Investigating brain metabolic networks is crucial for understanding the pathogenesis and functional alterations in Creutzfeldt-Jakob disease (CJD). However, studies on presymptomatic individuals remain limited. This study aimed to examine metabolic network topology reconfiguration in asymptomatic carriers of the PRNP G114V mutation.
View Article and Find Full Text PDFPLoS One
January 2025
Integrative Multiomics Lab, School of Bio Sciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India.
Background: Rheumatoid arthritis (RA) is a degenerative autoimmune disease, often managed through symptomatic treatment. The co-occurrence of the reported extra-articular comorbidities such as inflammatory bowel disease (IBD), and dementia may complicate the pathology of the disease as well as the treatment strategies. Therefore, in our study, we aim to elucidate the key genes, and regulatory elements implicated in the progression and association of these diseases, thereby highlighting the linked potential therapeutic targets.
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