The first examples of intramolecular Michael-type reactions of in situ-formed vinylnitroso compounds with carbon nucleophiles are reported. This methodology has been used to prepare a variety of ring systems including [3.2.1]-, [2.2.2]- and [2.2.1]-bridged carbobicyclic compounds, as well as a fused [5.5]-ring compound. Malonate anions have proven to be effective carbon nucleophiles in these conjugate addition reactions, and simple ester potassium enolates have also been successfully employed.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2615203 | PMC |
| http://dx.doi.org/10.1021/ja074108r | DOI Listing |
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