Background: The reorganisation of cancer services in England will result in the creation of specialist high volume cancer surgery centres. Studies have suggested a relationship between increasing surgical volume and improved outcomes in urological pelvic cancer surgery, although to date, they have pre-defined the definition of "high" and "low" volume surgeons.
Aim: To derive the minimum caseload a surgeon requires to achieve optimum outcomes and to examine the effect of the operating centre size upon individual surgeon's outcomes.
Methods: All cystectomies performed for bladder cancer in England over 5 years were analysed from Hospital Episode Statistics (HES) data. Statistical analysis was undertaken to describe the relationship between each surgeon's annual case volume and two
Outcome Measures: in-hospital mortality rate, and hospital stay. The surgeon's outcomes were then analysed with respect to the overall level of activity in their operating centre.
Results: A total of 6308 cystectomies were performed; the mean number of surgeons performing them annually was 327 with an overall mortality rate of 5.53%. A significant inverse correlation (-0.968, p<0.01) was found between case volume and mortality rate. Applying 95% confidence interval estimation, the minimum caseload required to achieve the lowest mortality rate was eight procedures per year. Increasing caseload beyond eight operations per year did not produce a significant reduction in mortality rate.
Conclusion: Analysis of HES data confirms an inverse relationship between surgeon's caseload and mortality for radical cystectomy. A caseload of eight operations per year is associated with the lowest mortality rate.
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http://dx.doi.org/10.1136/pgmj.2007.058214 | DOI Listing |
Polymers (Basel)
January 2025
Shandong Key Laboratory of Healthy Food Resources Exploration and Creation, School of Food Science and Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China.
As a veterinary drug, sulfamethazine is frequently used to control animal diseases. In this study, a novel molecularly imprinted photonic crystal sensor for the fast visual detection of sulfamethazine in milk and chicken has been developed. Under optimum preparation conditions, a molecularly imprinted, photonic crystal with an anti-opal structure and a clear bright color was prepared and characterized.
View Article and Find Full Text PDFSensors (Basel)
January 2025
Institute of Theoretical & Applied Informatics, Polish Academy of Sciences (IITiS-PAN), 44-100 Gliwice, Poland.
Edge computing systems must offer low latency at low cost and low power consumption for sensors and other applications, including the IoT, smart vehicles, smart homes, and 6G. Thus, substantial research has been conducted to identify optimum task allocation schemes in this context using non-linear optimization, machine learning, and market-based algorithms. Prior work has mainly focused on two methodologies: (i) formulating non-linear optimizations that lead to NP-hard problems, which are processed via heuristics, and (ii) using AI-based formulations, such as reinforcement learning, that are then tested with simulations.
View Article and Find Full Text PDFMicroorganisms
January 2025
Institute of Vegetable, Henan Academy of Agricultural Sciences, Graduate T&R Base of Zhengzhou University, Zhengzhou 450002, China.
strain PJH16, isolated and tested by our team, suppresses cucumber wilt as an efficient biocontrol agent. For further investigation, the strain has been combined with two other ( VJH504 and JNF2) to enhance biocontrol ability, which formed high-efficiency microbial agents in the current study. The methodological target taken is based on achieving the optimal growth conditions of the combined microbial agents; hence, the medium composition and culture conditions were optimized through a single-factor test, orthogonal test and response surface methodology.
View Article and Find Full Text PDFFood Chem
January 2025
College of Material Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, China. Electronic address:
An efficient, green, and novel basic deep eutectic solvent (DES)-assisted mechanochemical extraction method, combined with ultrahigh-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry, is proposed for simultaneous extraction and determination of target compounds from functional food. Several parameters are investigated using single-factor optimization, and response surface methodology is employed to determine the optimum extraction conditions. The conditions include a grinding time of 316.
View Article and Find Full Text PDFEnviron Sci Pollut Res Int
January 2025
Department of Chemistry, Institute of Technical Education and Research, Siksha 'O' Anusandhan Deemed to Be University, Khandagiri Square, Bhubaneswar, 751030, Odisha, India.
Due to limited resources of rare earth elements (REEs) and their high demand, these are subjected to supply constraints. So it is important to recover REEs from potential secondary resources. Phosphogypsum is the waste generated on an enormous scale (300 million metric tons per year) from the fertilizer industry.
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