This study investigated the development of contextual dependencies for sequential perceptual-motor learning on static features in the learning environment. In three experiments we assessed the effect of manipulating task irrelevant static context features in a serial reaction-time task. Experiment 1 demonstrated impaired performance after simultaneously changing display color, placeholder shape, and placeholder location. Experiment 2 showed that this effect was mainly caused by changing placeholder shape. Finally, Experiment 3 indicated that changing context affected both the application of sequence knowledge and the selection of individual responses. It is proposed either that incidental stimulus features are integrated with a global sequence representation, or that the changed context causes participants to strategically inhibit sequence skills.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367391 | PMC |
| http://dx.doi.org/10.1007/s00426-007-0123-5 | DOI Listing |
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Article Synopsis
- The L-arginine/agmatine transporter AdiC in E. coli is crucial for the bacterium's extreme acid resistance, yet little is known about how water molecules influence its structure and function.
- X-ray crystallography revealed the detailed structure of AdiC, highlighting the presence of numerous water molecules that help stabilize the protein and facilitate substrate binding through molecular dynamics simulations.
- The study identified a water-filled cavity at the interface of AdiC's dimers that is essential for their stability, and it proposed that the flexibility of certain gating residues plays a key role in the transport process.
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