The expression level of phase I (CYP1A1 and CYP1A2) and phase II (GST, and UGT) enzyme-coded genes were measured in liver microsomes of 30 Sprague-Dawley rats fed sea weed (Monostroma nitidum). Quantitative and qualitative analysis of the detoxifying enzymes were investigated using reverse transcription polymerase reaction (RT-PCR) and real time polymerase reaction (Real-time PCR) techniques. The antioxidative properties of seaweed were screened and investigated for its hepatoprotective activity in rat. There was no significant induction of GSTYa1, GSTYa2, and CYP1A2. However, an M. nitidum diet was found to significantly increase UGT1A1 and UGT1A6 mRNA levels and to decrease CYP1A1 mRNA levels in rat liver. Structural studies confirmed the presence of sulfated polysaccharides in the seaweed samples. The results demonstrate the potential of seaweed as a natural source of sulfated polysaccharide substances with potential use in chemoprevention medicine.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.fct.2007.06.014 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
PHENYLALANINE AMMONIA-LYASE 2 regulates secondary metabolism and confers manganese tolerance in Stylosanthes guianensis.
Plant Physiol
January 2025
Key Laboratory of Crop Gene Resources and Germplasm Enhancement in Southern China, Ministry of Agriculture and Rual Affairs/Tropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, China.
Stylo (Stylosanthes guianensis) is a tropical legume that exhibits considerable tolerance to manganese (Mn) toxicity, which severely constrains plant growth in acidic soils. To elucidate the Mn detoxification mechanisms in stylo, this study investigated the excess Mn-regulated metabolic profile of stylo roots and examined the role of metabolic enzymes in Mn tolerance. Excess Mn triggered oxidative stress in the two stylo genotypes tested.
View Article and Find Full Text PDFExploring novel pyrethroid resistance mechanisms through RNA-seq in from Colombia.
Curr Res Insect Sci
December 2024
Grupo Biología y Control de Enfermedades Infecciosas, Universidad de Antioquia, Medellín 050010, Colombia.
Pyrethroids are the most widely used insecticides for controlling insect vectors carrying medically and economically significant pathogens. In Colombia, studies on triatomine insecticide resistance are limited. Due to the increasing challenge of insecticide resistance, this work focuses on determining resistance to different pyrethroid insecticides in populations of from Colombia.
View Article and Find Full Text PDFInsights into the salinity tolerance of the succulent halophyte : comparative ecophysiology of plants from heteromorphic seeds.
Front Plant Sci
December 2024
Department of Microbiology and Molecular Biology, Brigham Young University, Provo, UT, United States.
Introduction: Little is known about the similarities and differences in responses of plants grown from heteromorphic seeds, which are morpho-physiologically dissimilar seeds produced simultaneously on the same plant.
Methods: In this context, we studied how plants grown from heteromorphic (i.e.
In Search for Inhibitors of Human Aldo-Keto Reductase 1B10 (AKR1B10) as Novel Agents to Fight Cancer and Chemoresistance: Current State-of-the-Art and Prospects.
J Med Chem
January 2025
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno D'Alcontres, 31-98166 Messina, Italy.
Aldo-keto reductase 1B10 (AKR1B10) is a human enzyme that catalyzes the NADPH-dependent reduction of several different carbonyl compounds to the corresponding alcohols. Under physiological conditions, AKR1B10 is expressed mainly in the gastrointestinal tract, where it can detoxify reactive carbonyl compounds derived from dietary sources and xenobiotics. AKR1B10 is highly expressed in several cancers and precancerous conditions, proving to be crucially implicated in carcinogenesis and to function as a prognostic indicator of tumor development.
View Article and Find Full Text PDFProteomic evaluation of pathways associated with phosphine-induced mitochondrial dysfunction and resistance mechanisms in Tribolium castaneum against phosphine fumigation: Whole and partial proteome identification.
Ecotoxicol Environ Saf
January 2025
Department of Applied Biosciences, Kyungpook National University, Daegu 41566, South Korea; Department of Integrative Biology, Kyungpook National University, Daegu 41566, South Korea. Electronic address:
Phosphine (PH) fumigation is widely used to control insect pests in stored products globally. However, intensive PH use has led to the emergence of significant resistance in target insects. To address this issue, this study investigated PH resistance mechanisms by conducting both qualitative and quantitative proteomic analyses on the whole proteome of a PH-resistant Tribolium castaneum strain (AUS-07) using LC-MS/MS.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!