AI Article Synopsis
- The study focused on creating new antitumor agents by designing and synthesizing compounds called 2,6-diaryl-substituted pyridine derivatives, which contain three aryl groups.
- Out of 18 compounds tested, most exhibited moderate cytotoxicity against various human cancer cell lines.
- The results suggest that the number of aryl groups in these compounds plays a significant role in their effectiveness as antitumor agents.
Article Abstract
For the development of novel antitumor agents, we designed and synthesized 2,6-diaryl-substituted pyridine derivatives bearing three aryl groups, which are the bioisosteres of terpyridine, and evaluated their biological activities. Most of the 18 prepared compounds showed moderate cytotoxicity against several human cancer cell lines. From the structure-activity relationships we may conclude that the number of aryl groups employed would be critical for their biological activities.
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| http://dx.doi.org/10.1016/j.ejmech.2007.05.002 | DOI Listing |
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