Severity: Warning
Message: fopen(/var/lib/php/sessions/ci_session3kketge0ar04ujd6s7j8ssubt6irjdsl): Failed to open stream: No space left on device
Filename: drivers/Session_files_driver.php
Line Number: 177
Backtrace:
File: /var/www/html/index.php
Line: 316
Function: require_once
Severity: Warning
Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)
Filename: Session/Session.php
Line Number: 137
Backtrace:
File: /var/www/html/index.php
Line: 316
Function: require_once
Severity: Warning
Message: file_get_contents(https://...@gmail.com&api_key=61f08fa0b96a73de8c900d749fcb997acc09&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
Filename: helpers/my_audit_helper.php
Line Number: 197
Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 197
Function: file_get_contents
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 271
Function: simplexml_load_file_from_url
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3145
Function: getPubMedXML
File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global
File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword
File: /var/www/html/index.php
Line: 316
Function: require_once
The modern inhibitors of gastric acid secretion reduce very efficiently the aggressiveness of gastroesophageal reflux but they appear to modify the pathophysiological situation in a way that favours the development of Barrett's esophagus (BE). During the last two decades, the prevalence of BE in the population submitted to endoscopy has clearly increased while the peptic stricture of the esophagus is fast disappearing. With a reduced tendency to stricture and fibrosis, the esophagus seems more prone to the columnar metaplasia. This suggests that the factor that promotes the columnar metaplasia reaches the areas of esophagitis through the esophageal wall. In the conditions of an advanced reflux disease, the veins crossing the gastroesophageal junction would be well suited to the transport of this factor, provided they have not been obliterated by thrombosis or fibrosis. The veins do not normally participate in the metabolic activity but their permeability may be altered in a pathological environment. In the esophageal wall submitted to an important reflux, the environment cannot be normal, as evidenced by the alterations of the esophageal motricity. Furthermore, these veins are submitted to the peristaltic activity of the esophagus.
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Source |
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http://dx.doi.org/10.1016/j.icvts.2003.12.002 | DOI Listing |
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