This study was carried out in 59 patients with histological evidence of pulmonary sarcoidosis. In all patients, bronchoalveolar lavage (BAL) and transbronchial biopsy (TBB) were performed simultaneously. In histologic specimens of TBB, 24/59 (41%) patients had luminal alveolitis, 36/59 (61%) mural alveolitis, 41/59 (69%) granulomas 11/59 (15%) diffuse fibrosis and 24/59 (41%) focal fibrosis. Cytological examinations of BAL revealed 22/59 (37%) patients without alveolitis, 20/59 (34%) with low intensity alveolitis and 17/59 (29%) with high intensity alveolitis. Comparative analysis of these patients showed the association of the alveolitis in BAL and the mural alveolitis or granulomas in TBB (p less than 0.01). The conclusion of this study is that cytological findings in BAL represent interstitial cells very well.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
A Clinical Metaproteomics Workflow Implemented within Galaxy Bioinformatics Platform to Analyze Host-Microbiome Interactions Underlying Human Disease.
J Vis Exp
January 2025
Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota;
Clinical metaproteomics reveals host-microbiome interactions underlying diseases. However, challenges to this approach exist. In particular, the characterization of microbial proteins present in low abundance relative to host proteins is difficult.
View Article and Find Full Text PDFDiffuse Alveolar Hemorrhage Associated With Anti-PL-7 Antisynthetase Syndrome: A Case Report.
Case Rep Pulmonol
January 2025
Prisma Health, University of South Carolina-School of Medicine, Columbia, South Carolina, USA.
Diffuse alveolar hemorrhage (DAH) is a potentially life-threatening condition which can present with hemoptysis, diffuse alveolar infiltrates, anemia, and hypoxic respiratory failure. Antisynthetase syndrome (AS) is a rare autoimmune disorder most often characterized by nonerosive arthritis, proximal muscle weakness with elevated muscle enzymes, Raynaud's phenomenon, hyperkeratosis of the digits (mechanic's hands), and interstitial lung disease. According to large population studies, AS has an annual incidence of 0.
View Article and Find Full Text PDFSarcoidosis as an Uncommon Cause of Chest Pain: A Case Report.
Cureus
January 2025
Internal Medicine, Hospital Senhora da Oliveira, Guimarães, PRT.
Sarcoidosis is a multisystem granulomatous disease of unknown etiology. Despite primarily affecting the lung, sarcoidosis can affect any organ, resulting in various clinical manifestations. We present a case of a 56-year-old man who developed thoracic pain over several months along with skin lesions.
View Article and Find Full Text PDFImpact of Herpesvirus Detection via Metagenomic Next-Generation Sequencing in Patients with Lower Respiratory Tract Infections.
Infect Drug Resist
January 2025
Department of Respiratory and Critical Care Medicine, The Affiliated People's Hospital of Ningbo University, Yinzhou People's Hospital, Ningbo, Zhejiang, 315040, People's Republic of China.
Purpose: This study aimed to investigate the impact of herpesvirus detection by metagenomic next-generation sequencing (mNGS) of bronchoalveolar lavage fluid (BALF) on lower respiratory tract infections (LRTIs) patients' lung microbiome composition and prognosis.
Patients And Methods: We initially enrolled 234 hospitalized patients with LRTIs who underwent BALF mNGS between February 2022 and May 2023. The study analyzed the clinical manifestations and the pulmonary microbial composition between herpesvirus detection (HD) and non-herpesvirus detection (non-HD) group.
Chronic Cough, Dyspnea, and a Novel CCDC39 Variant: A Case Report of Heterotaxy Syndrome Without Cardiac Anomalies and Associated Primary Ciliary Dyskinesia.
Cureus
December 2024
Pulmonology, Algemeen Ziekenhuis Glorieux, Ronse, BEL.
Heterotaxy syndrome is characterized by abnormal left-right arrangement of thoracoabdominal organs and is frequently associated with complex cardiac anomalies. However, cases with predominant extracardiac manifestations are increasingly recognized. This report describes a 20-year-old female of North African descent with consanguineous parentage, who presented with chronic cough and exertional dyspnea persisting over several years.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!