AI Article Synopsis
- Eleven patients with well-controlled psoriasis on cyclosporine participated in a study to transition to alefacept.
- 64% of participants maintained their improvement in psoriasis severity after switching medications, as indicated by PGA scores.
- All patients experienced improved or stable quality of life, and side effects were similar to those seen during previous alefacept treatments.
Article Abstract
Eleven patients with well-controlled psoriasis on cyclosporine (Physician's Global Assessment [PGA] of "mild" or better) participated in an open-label study that evaluated a strategy for transition to alefacept. Using this transition strategy, 7 of 11 patients (64%) maintained PGA scores. Quality of life improved or was maintained in all patients. Adverse events and reductions in CD4+ T cell counts were consistent with those seen during alefacept monotherapy.
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