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Intestinal Foxl1+ cell-derived CXCL12 maintains epithelial homeostasis by modulating cellular metabolism.
Int Immunol
January 2025
Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
Several mesenchymal cell populations are known to regulate intestinal stem cell (ISC) self-renewal and differentiation. However, the influences of signaling mediators derived from mesenchymal cells other than ISC niche factors on epithelial homeostasis remain poorly understood. Here, we show that host and microbial metabolites, such as taurine and GABA, act on PDGFRαhigh Foxl1high sub-epithelial mesenchymal cells to regulate their transcription.
View Article and Find Full Text PDFTaurine Supplementation Alleviates Blood Pressure via Gut-Brain Communication in Spontaneously Hypertensive Rats.
Biomedicines
November 2024
Department of Nephrology, The First Affiliated Hospital of Xi'an Medical University, Xi'an 710077, China.
Objects: Taurine exhibits protective effects in the context of cardiovascular pathophysiology. A range of evidence suggests that hypertension activates inflammatory responses and oxidative stress in the paraventricular nucleus (PVN), elevating the arterial tone and sympathetic activity, while it induces gut-brain axis dysfunction in the context of hypertension. However, the mechanism underlying taurine's anti-hypertensive effects via the gut-brain axis remains unclear.
View Article and Find Full Text PDFUnveiling the Therapeutic Potential of Berberine in Rheumatoid Arthritis: A Comprehensive Study of Network Pharmacology, Metabolomics, and Intestinal Flora.
J Inflamm Res
December 2024
College of Acupuncture-Moxibustion and Orthopedics, Hubei University of Chinese Medicine, Wuhan, People's Republic of China.
Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease influenced by environmental triggers, including the commensal microbiota. Recent research has highlighted distinctive features of the gut microbiota in RA patients. This study investigates the therapeutic potential of berberine (BBR), a gut microbiota modulator known for its significant anti-RA effects, and elucidates the underlying mechanisms.
View Article and Find Full Text PDFEpithelial NSD2 maintains FMO-mediated taurine biosynthesis to prevent intestinal barrier disruption.
Clin Transl Med
December 2024
State Key Laboratory of Systems Medicine for Cancer, Renji-Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Background: Inflammatory bowel disease (IBD) presents a significant challenge due to its intricate pathogenesis. NSD2, a histone methyltransferase responsible for dimethylating histone 3 at lysine 36, is associated with transcriptional activation. NSD2 expression is decreased in both the intestinal epithelial cells (IECs) of IBD patients and the IBD mouse model.
View Article and Find Full Text PDFDietary betaine supplementation has been reported to alleviate the adverse effects of high-carbohydrate diets on , while the regulatory mechanism remains largely unknown. In the present study, a 79-day feeding trial was conducted with 450 juvenile (average weight 6.75 ± 0.
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