Introduction: The aim was to monitor the changes in haemocoagulation parameters in healthy volunteers after a thrombotripsy with 1-hour transcranial Doppler monitoring using a 2-4 MHz probe.
Materials And Methods: About 10 healthy volunteers underwent a 1-hour thrombotripsy of the middle cerebral artery (MCA), thrombotripsy of the radial artery and a standard 20-min neurosonologic examination (NSE) in 2-week intervals. Platelet count, aPTT, prothrombin time, fibrinogen, D-dimers, tPA, FDP, alpha-2-antiplasmin (AP), plasminogen, PAI-1 antigen, time of euglobulin clot lysis (ECL), homocysteine, and lipoprotein (a) were examined before, at the end and 24 h after a thrombotripsy. All adverse events were monitored.
Results: After a thrombotripsy of the MCA, PAI-1 antigen, tPA antigen, fibrinogen and AP activity were significantly decreased by a mean of 32, 23, 7, and 4% respectively (P < 0.05 in all cases). After a thrombotripsy of the RA, there was a significant decrease in tPA antigen alone by an average of 14% (P < 0.05). Standard NSE did not affect any of the measured factors.
Conclusions: Thrombotripsy with 1-hour TCD monitoring using a 2-4 MHz diagnostic probe may affect the fibrinolytic system in humans.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s11239-007-0079-8 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Influence of Axial Rotation Between the Femoral Neck and Ankle Joint on Kinematics in Normal Knees: A Cross-Sectional Study.
J Am Acad Orthop Surg Glob Res Rev
January 2025
From the Department of Orthopedic Surgery, Faculty of Medicine, The University of Tokyo, Bunkyo, Tokyo (Dr. Kono, Dr. Taketomi, Dr. Kage, Dr. Inui, and Dr. Tanaka); the Department of Information Systems, Faculty of Engineering, Saitama Institute of Technology, Fukaya, Saitama (Dr. Yamazaki); the Department of Orthopedic Biomaterial Science, Osaka University Graduate School of Medicine, Suita, Osaka (Dr. Tamaki, and Dr. Tomita); the Department of Orthopedic Surgery, Saitama Medical University, Saitama Medical Center, Kawagoe, Saitama (Dr. Inui); and the Department of Health Science, Graduate School of Health Science, Morinomiya University of Medical Sciences, Suminoe, Osaka, Japan (Dr. Tomita).
Background: The effect of axial rotation between the femoral neck and ankle joint (total rotation [TR]) on normal knees is unknown. Therefore, this study aimed to investigate the TR effect on normal knee kinematics.
Methods: Volunteers were divided into groups large (L), intermediate (I), and small (S), using hierarchical cluster analysis based on TR in the standing position.
Background: Except host and environmental factors influencing individual human cytokine responses, pre-analytical handling procedures and detection methods also affect cytokine levels.
Methods: In this study, we used cytometric bead array (CBA) and chemiluminescence (ECL). These two methods were used to test serum and plasma samples from 50 healthy adult volunteers and 50 rheumatoid arthritis (RA) patients' cytokine levels.
Integrated analysis of non‑coding RNAs (HOTAIR and miR‑130a) and their cross‑talk with TGF‑β1, SIRT1 and E‑cadherin as potential biomarkers in colorectal cancer.
Oncol Lett
March 2025
Department of Biochemistry, Faculty of Science, Beni-Suef University, Beni-Suef 62511, Egypt.
Molecular changes have a substantial impact on the onset of colorectal cancer (CRC). Complexes of HOTAIR and miRNAs disrupt several cellular functions during carcinogenesis, primarily by disrupting several carcinogenic signaling pathways. In the present study, the relationships between the serum levels of transforming growth factor-β1 (TGF-β1), sirtuin-1 (SIRT1) and E-cadherin and those of HOX transcript antisense intergenic RNA (HOTAIR) and microRNA-130a (miR-130a) in individuals with CRC were analyzed, including their correlations and diagnostic potential.
View Article and Find Full Text PDFRandomised, placebo-controlled, double-blinded, four-way crossover trial to demonstrate the comparative pharmacodynamic equivalence of a non-invasive diagnostic test for adrenal insufficiency in a healthy population: the STARLIT-2 study protocol.
BMJ Open
December 2024
Clinical Medicine, School of Medicine and Population Health, The University of Sheffield, Sheffield, UK
Introduction: Cortisol is an essential stress hormone and failure of its production, known as adrenal insufficiency (AI), is associated with significant mortality due to adrenal crisis. The Short Synacthen Test (SST) is the current diagnostic test of choice for AI, but it is both invasive and resource intensive. Globally, there is an unmet need for a non-invasive, cost-effective test.
View Article and Find Full Text PDFThe known genetic variants of BRCA1, BRCA2 and NOD2 in pancreatitis and pancreatic cancer risk assessment.
Sci Rep
January 2025
Institute of Medical Sciences, Jan Kochanowski University of Kielce, Kielce, Poland.
The single nucleotide polymorphism in NOD2 (rs2066847) is associated with conditions that may predispose to the development of gastrointestinal disorders, as well as the known BRCA1 and BRCA2 variants classified as risk factors in many cancers. In our study, we analyzed these variants in a group of patients with pancreatitis and pancreatic cancer to clarify their role in pancreatic disease development. The DNA was isolated from whole blood samples of 553 patients with pancreatitis, 83 patients with pancreatic cancer, 44 cases of other pancreatic diseases, and 116 healthy volunteers.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!