To understand the diversity of skin color now observed in people of the five continents, one has to go back in history. In fact, geology, archeological findings, biology and medical science, as well as anthropology, linguistics, and contemporary genetic techniques enable us to patch up a clear picture of the past up to the present - the evolution of the Homo sapiens. Owing to its undeniable visibility, skin color has always had a sociologic connotation, which has up to the present time caused division between people.
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http://dx.doi.org/10.1016/j.det.2007.05.001 | DOI Listing |
J Craniofac Surg
January 2025
School of Plastic Surgery, Shandong Second Medical University.
Patients with localized scleroderma on the face typically exhibit asymmetrical linear or patchy skin lesions and indentations on areas such as the scalp and forehead, with a smooth, waxy surface. In the early stages, medication is used to control the progression of the disease. In later stages, plastic surgery is performed to repair facial skin lesions.
View Article and Find Full Text PDFSkinmed
January 2025
Division of Dermatology, Department of Medicine, Albert Einstein College of Medicine, Montefiore Hospital, Bronx, NY.
A 15-year-old African-American man (Fitzpatrick skin type V) presented to the outpatient dermatology clinic with a large, verrucous, exophytic mass measuring 3.5 × 2.3 cm on the right lateral side of the posterior flank (Figure 1).
View Article and Find Full Text PDFNat Commun
January 2025
NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust & University College London Institute of Ophthalmology, London, UK.
Few metrics exist to describe phenotypic diversity within ophthalmic imaging datasets, with researchers often using ethnicity as a surrogate marker for biological variability. We derived a continuous, measured metric, the retinal pigment score (RPS), that quantifies the degree of pigmentation from a colour fundus photograph of the eye. RPS was validated using two large epidemiological studies with demographic and genetic data (UK Biobank and EPIC-Norfolk Study) and reproduced in a Tanzanian, an Australian, and a Chinese dataset.
View Article and Find Full Text PDFScience
January 2025
Department of Marine Bioscience, Atmosphere and Ocean Research Institute, The University of Tokyo, Kashiwa, Japan.
The recent discovery of nonvisual photoreceptors in various organs has raised expectations for uncovering their roles and underlying mechanisms. In this work, we identified a previously unrecognized hormone-releasing mechanism in the pituitary of the Japanese rice fish (medaka) induced by light. Ca imaging analysis revealed that melanotrophs, a type of pituitary endocrine cell that secretes melanocyte-stimulating hormone, robustly increase the concentration of intracellular Ca during short-wavelength light exposure.
View Article and Find Full Text PDFJ Cancer
January 2025
Department of Information and Communication Engineering, Yeungnam University, Gyeongsan, 38541, Republic of Korea.
Faced with anomalies in medical images, Deep learning is facing major challenges in detecting, diagnosing, and classifying the various pathologies that can be treated via medical imaging. The main challenges encountered are mainly due to the imbalance and variability of the data, as well as its complexity. The detection and classification of skin diseases is one such challenge that researchers are trying to overcome, as these anomalies present great variability in terms of appearance, texture, color, and localization, which sometimes makes them difficult to identify accurately and quickly, particularly by doctors, or by the various Deep Learning techniques on offer.
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