Homocysteine (Hcy) and C-reactive protein (CRP) are novel risk factors for osteoporosis. The purpose of this analysis was to determine the relationship of Hcy and CRP to volumetric trabecular bone, but also to assess their relationship to areal composite bone in healthy postmenopausal women (N=184). We used peripheral quantitative computed tomography to assess volumetric bone at the distal tibia and dual-energy X-ray absorptiometry to assess areal composite bone at the proximal femur and lumbar spine. Multiple regression revealed that 22% of the variability in trabecular bone mineral content (F=9.59, p
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2131712 PMC http://dx.doi.org/10.1016/j.jocd.2007.06.002 DOI Listing Publication Analysis
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A data-driven framework for developing a unified density-modulus relationship for the human lumbar vertebral body.
J Mech Behav Biomed Mater
January 2025
Department of Mechanical Engineering, Boston University, Boston, MA 02215, USA; Center for Multiscale and Translational Mechanobiology, Boston University, Boston, MA 02215, USA; Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA.
Despite the broad agreement that bone stiffness is heavily dependent on the underlying bone density, there is no consensus on a unified relationship that applies to both cancellous and cortical compartments. Bone from the two compartments is generally assessed separately, and few mechanical test data are available for samples from the transitional regions between them. In this study, we present a data-driven framework integrating experimental testing and numerical modeling of the human lumbar vertebra through an energy balance criterion, to develop a unified density-modulus relationship across the entire vertebral body, without the necessity of differentiation between trabecular and cortical regions.
View Article and Find Full Text PDFImpact of intravenous CT contrast agents on internal calibration techniques to determine trabecular BMD of the lumbar spine.
Eur J Radiol
January 2025
Department of Medicine 3, Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany; Institute of Medical Physics, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany. Electronic address:
Objectives: Contrast agents are frequently administered in computed tomography (CT) scans used for opportunistic screening of osteoporosis. The objective of this study is to compare the impact of contrast-related bone mineral density (BMD) increase between phantom-based and internal CT calibration techniques.
Materials And Methods: Phantom-based and internal CT calibration techniques were used to determine trabecular BMD in 93 existing clinical CT scans of the lumbar spine of 34 subjects, scanned before and after administration of contrast agents.
Improvement of bone properties in children with osteogenesis imperfecta after pamidronate: a bone biopsy study.
JBMR Plus
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INSERM UMR 1033, Univ Lyon, Université Claude Bernard Lyon 1, F-69008 Lyon, France.
OI, or bone brittle disease, is characterized by increased mineralization of bone matrix independently of clinical severity. So, a beneficial effect of antiresorptive treatments such as bisphosphonates (BP) is questionable. We aim to compare the bone matrix characteristics before and after BP pamidronate (PAM).
View Article and Find Full Text PDFProtective effects of Lactobacillus plantarum strain against protein malnutrition-induced muscle atrophy and bone loss in juvenile mice.
PLoS One
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School of Biological Sciences, Seoul National University, Seoul, South Korea.
Early-life malnutrition adversely affects nearly all organ systems, resulting in multiple physiological adaptations, including growth restriction and muscle and bone loss. Although there is growing evidence that probiotics effectively improve systemic growth under malnourished conditions in different animal models, our knowledge of the beneficial effects of probiotics on various organs is limited. Here, we show that Lactobacillus plantarum strain WJL (LpWJL) can mitigate skeletal muscle and bone loss in protein-malnourished juvenile mice.
View Article and Find Full Text PDFThe effects of type 1 and type 2 diabetes mellitus on bone health in chronic kidney disease.
Nat Rev Endocrinol
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Department of Renal Medicine, Westmead Hospital, Westmead, New South Wales, Australia.
Fracture is an under-recognized but common complication of diabetes mellitus, with an incidence approaching twofold in type 2 diabetes mellitus (T2DM) and up to sevenfold in type 1 diabetes mellitus (T1DM) compared with that in the general population. Both T1DM and T2DM induce chronic hyperglycaemia, leading to the accumulation of advanced glycosylation end products that affect osteoblast function, increased collagen crosslinking and a senescence phenotype promoting inflammation. Together with an increased incidence of microvascular disease and an increased risk of vitamin D deficiency, these factors reduce bone quality, thereby increasing bone fragility.
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