AI Article Synopsis
- Invasive aspergillosis significantly impacts patients with blood cancers and those who have had stem cell transplants, leading to high rates of illness and death.
- Early detection and treatment are crucial to enhance patient outcomes, but diagnosing the disease early can be challenging.
- PCR-based tests have become promising options in recent years for better diagnosis and management of the disease, but their widespread use in labs is limited due to inconsistent standards.
Article Abstract
Invasive aspergillosis is a major cause of morbidity and mortality in patients with hematological malignancies and stem cell transplant recipients. Early diagnosis and therapy are important to improve prognosis in these patients. Difficulties in establishing an early diagnosis have prompted investigations towards new and alternative diagnostic methods. During the last decade, PCR-based assays have emerged as valuable experimental tools to improve diagnostic workup and clinical management of patients with suspected or proven invasive aspergillosis. However, implementation of these molecular tools in the routine diagnostic laboratory is hampered by a lack of standardization.
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| http://dx.doi.org/10.2217/17460913.1.3.283 | DOI Listing |
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is the etiologic agent of invasive aspergillosis, a life- threatening fungal pneumonia that is initiated by the inhalation of conidia (spores) into the lung. If the conidia are not cleared, they secrete large quantities of hydrolytic enzymes and toxins as they grow, resulting in extensive damage to pulmonary tissue. Stromal fibroblasts are central responders to tissue damage in many organs, but their functional response to pulmonary injury caused by has not been explored.
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Article Synopsis
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