Purpose: To study the expression and clinical significance of M-phase promoting factor (MPF) in salivary adenoid cystic carcinoma (SACC).
Methods: The expression of MPF was investigated in 40 salivary adenoid cystic carcinomas and 40 normal salivary tissues by immunohistochemistry. The expression of MPF was detected in SACC-83 and SACC-LM with Western blot. Pearson's Chi-square test, paired t test and linear correlation analysis were used to analyze the data with SPSS 11.5 software package.
Results: The expression of MPF was significantly higher in salivary adenoid cystic carcinoma than in normal salivary tissues(P<0.05). There was significant correlation between the level of MPF expression and pathological type(P<0.05). The expression of MPF was significantly higher in SACC-LM than in SACC-83 (P<0.05).
Conclusions: MPF highly expressed in salivary adenoid cystic carcinoma, salivary adenoid cystic carcinoma correlated with the expression of MPF and the abnormal activation of MPF was one of the factors for the proliferation of salivary adenoid cystic carcinoma. Metastasis in salivary adenoid cystic carcinoma correlated with the expression of MPF.
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