Aim: To study the loss of heterozygosity (LOH) at 8p21-23 locus in diffuse gastric cancer.
Methods: To evaluate the involvement of this region in gastric cancer, we used eight microsatellite markers covering two Mb of mentioned region, to perform a high-resolution analysis of allele loss in 42 cases of late diffuse gastric adenocarcinoma.
Results: Six of these STS makers: D8S1149, D8S1645, D8S1643, D8S1508, D8S1591, and D8S1145 showed 36%, 28%, 37%, 41%, 44% and 53% LOH, respectively.
Conclusion: A critical region of loss, close to the NAT2 locus and relatively far from FEZ1 gene currently postulated as tumor suppressor gene in this region.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172716 | PMC |
| http://dx.doi.org/10.3748/wjg.v13.i24.3354 | DOI Listing |
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