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Organocatalytic conjugate addition of formaldehyde N,N-dialkylhydrazones to beta,gamma-unsaturated alpha-keto esters. | LitMetric

Organocatalytic conjugate addition of formaldehyde N,N-dialkylhydrazones to beta,gamma-unsaturated alpha-keto esters.

Org Lett

Instituto de Investigaciones Químicas, CSIC-USe, c/ Américo Vespucio 49, Isla de la Cartuja, 41092 Seville, Spain, and Departamento de Química OrgAnica, Facultad de Química, Universidad de Sevilla, Apdo. de Correos No. 553, 41071 Seville, Spain.

Published: August 2007

(1S,2R)-1-Aminoindan-2-ol-derived thioureas behave as efficient H-bonding organocatalysts for the nucleophilic conjugate addition of formaldehyde hydrazones to beta,gamma-unsaturated alpha-keto esters as enoate surrogates, affording the corresponding adducts in good yields and enantioselectivities.

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Source
http://dx.doi.org/10.1021/ol071292cDOI Listing

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