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Intramicellar sensor assays: Improving sensing sensitivity of sensor array for thiol biomarkers.
Biosens Bioelectron
January 2025
Liaoning Province Key Laboratory for Green Synthesis and Preparative Chemistry of Advanced Materials, Liaoning University, Shenyang, 110036, PR China; School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore, 637371, PR Singapore. Electronic address:
Array-based analysis allows for precise disease diagnosis by simultaneously detecting multiple biomarkers. However, most array sensing platforms rely on non-covalent interactions between sensors and analytes, which limits their sensitivity. This study enhances the sensitivity of array analysis for thiol biomarkers by incorporating polyion complex micelles into the sensor array design.
View Article and Find Full Text PDFSensing array based on imidazole-regulated Cu@MOFs nanozymes with enhanced laccase-like activity for the discrimination of phenolic pollutants.
Anal Chim Acta
February 2025
School of the Environment and Safety Engineering, School of the Emergency Management, Jiangsu University, Zhenjiang, 212013, China; Center for Medical Laboratory Science, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, 533000, China; Key Laboratory of Clinical Molecular Diagnosis and Research for High Incidence Diseases in Western Guangxi, Guangxi, 533000, China. Electronic address:
Background: Phenolic pollutants with high toxicity and low biodegradability can disrupt environmental balance and severely affect human health, whereas existing methods are difficult to implement the rapid and high-throughput detection of multiple phenolic pollutants.
Results: Herein, we developed a four-dimensional colorimetric sensor array based on imidazole-modulated Cu@MOFs for distinguishing and determining phenolic pollutants. Wherein, four Cu@MOFs (ATP@Cu, ADP@Cu, AMP@Cu, and GMP@Cu) nanozyme with laccase-like activity were firstly prepared, and a novel strategy of imidazole-containing molecules-regulated was proposed to improve the laccase-like activity of Cu@MOFs nanozymes.
Development of 3D-printed conducting microneedle-based electrochemical point-of-care device for transdermal sensing of chlorpromazine.
J Mater Chem B
January 2025
Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Raleigh, NC 27695, USA.
Despite the various benefits of chlorpromazine, its misuse and overdose may lead to severe side effects, therefore, creating a user-friendly point-of-care device for monitoring the levels of chlorpromazine drug to manage the potential side effects and ensure the effective and safe use of the medication is highly desired. In this report, we have demonstrated a simple and scalable manufacturing process for the development of a 3D-printed conducting microneedle array-based electrochemical point-of-care device for the minimally invasive sensing of chlorpromazine. We used an inkjet printer to print the carbon and silver ink onto a customized 3D-printed ultrasharp microneedle array for the preparation of counter, working, and reference electrodes.
View Article and Find Full Text PDFA Novel Array-Based Fluorescent Sensing Approach for the Identification and Quantification of Pesticides with High Sensitivity Based on Distinguishable Cross-response Algorithm.
J Fluoresc
January 2025
Chongqing Engineering and Technology Research Center of Intelligent Rehabilitation and Eldercare, Chongqing City Management College, 401331, Chongqing, China.
The presence of excessive residues of pesticides poses a great threat to ecology and human health. Herein, a novel, low-cost, simple and precise quantification sensing platform was established for differentiating and monitoring four common pesticides in China. Particularly, the array-based ratio fluorescent sensor array detector (ARF-SAD) based on cross-reaction characteristics of porphyrins and other porphyrin derivative was successfully constructed and integrated into the platform.
View Article and Find Full Text PDFA colorimetric sensor array for the rapid identification of benzylisoquinoline alkaloids and Coptidis Rhizoma based on urease inhibition.
Food Chem
December 2024
State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR China. Electronic address:
Benzylisoquinoline alkaloids are significant phyto-nutraceuticals with a bitter flavor. However, due to their complex structures, the sensing and identification of benzylisoquinoline alkaloids is challenging. Benzylisoquinoline alkaloids are commonly extracted from plants such as Coptidis Rhizoma (CR), while the adulteration and dyeing of CR are prevalent.
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